Three years old boy presented with recurrent severe abdominal pain. He was treated for constipation and the pain resolved. Later he developed a limitation of neck movements. Investigations revealed a spinal cord mass. After surgical resection, histopathology confirmed pilocytic astrocytoma.

T-cell large granular lymphocytic leukemia (T-LGL) is a chronic malignancy characterized by clonal expansion of cytotoxic T-cells possibly complicated by cytopenias of one or more myeloid lineages. By describing a multiply-refractory T-LGL case, this report highlights the importance of molecular-targeted and non-cytotoxic therapies in the context of frail elderly patients.

Gastric cancer rarely disseminates to the bone. Initial clinical presentation of bone metastasis without any preceding gastrointestinal symptoms in gastric cancer patient is also extremely infrequent. Herein, we report an original case of gastric cancer revealed by a pathologic fracture due to bone metastasis.

Immunohistochemical studies have revealed that the tumor of a patient with basal cell carcinoma exhibited activation of the Hedgehog and Wnt/β-catenin signaling pathways. The glioma-associated oncogene1 overexpression leads to transcriptional activation making it an attractive molecular target in anticancer therapies due to the main downstream effectors of the cascade.

We encountered a case in which a recurrent condyloma-like papillary tumor was repeatedly treated as condyloma. Therefore, the patient was re-diagnosed and treated for non-invasive cervical papillary squamous cancer (PSCC) with HPV6 infection. To the best of our knowledge, this is the first report of HPV6 infection in PSCC.

The sternum is an exceptional localization for Diffuse Large B Cells Lymphoma. A Case of a man with a sternal mass that mimics a sarcoma on the CT scan. Needle biopsy was not contributive. Surgical resection was indicated because of a local progression. Histopathological examination concluded to a primary DLBCL

Large cell neuroendocrine carcinoma (LCNEC) was first proposed by Travis et al. in 1991 and subsequently classified as high grade neuroendocrine carcinoma (HGNEC) by the world health organization. It is a rare tumor with unclear clinicopathologic features. Herein, we describe a rare case of LCNEC with a unique Cushing’s presentation.

Pediatric chronic myeloid leukemia is a rare entity (2-5% of childhood leukemias) classified as a myeloproliferative neoplasia characterized by the presence of the BCR-ABL fusion gene, the oncogenic translocation product (9; 22) responsible for the disease through its deregulated tyrosine kinase activity.

The choice of patient for a single lung resection is challenging for the surgeon. This report is presenting our experience in surgical treatment for patient with metastatic synovial sarcoma who initially underwent total left pneumonectomy and to identify possible predictors for the selection of patients who may undergo surgical treatment.

Lentigines are brown macules which represent increased proliferation of melanocytes at the dermo-epidermal junction. We report three cases of acral lentiginosis in children following chemotherapy for acute lymphoblastic leukaemia (ALL) which have persisted following cessation of chemotherapy, despite avid photoprotection.

Those patients with hypopharyngoesophageal cancer often sacrificed larynx before reconstruction using jejunum to restore the continuity of the digestive tract and allow oral alimentation. We retrospectively collected and analyzed three patients who underwent hypopharyngoesophageal reconstruction by free partial patch and partial tube jejunal graft transfer with reservation of laryngeal function caused by hypopharyngeal cancer invading the cervical esophagus. The partial patch and partial tube jejunal graft transfer survival rate was 100%(3/3). The larynx was reserved in the three patients. The partial patch and partial tube jejunal graft transfer is a safe and reliable choice for reconstruction of large and complex defects after pharyngectomy and cervical esophagectomy with larynx preserved.

Key Points: 1. We have identified ambiguity in the current guidance on thyroid MDT’s, and have also found nationwide variation in compliance with this. 2. We recommend: a. All surgeons undertaking thyroid surgery should complete a minimum of 20 thyroid procedures per year, and this should also form part of surgeons’ annual appraisal. b. All surgeons should contribute data to UKRETS (unless prevented by local legal frameworks) and this should form part of surgeons’ annual appraisal and be audited by individual MDT’s and regional cancer networks. c. Thyroid MDT’s should be held weekly where possible, with a minimum frequency of fortnightly. d. The core membership of a thyroid MDT (stand alone and joint) should include thyroid surgeons, specialist radiology, endocrinology, nuclear medicine, nurse specialists, histopathology +/- cytology and clinical oncology.

Chronic myeloid leukemia (CML) is a myeloproliferative disorder due to translocation between chromosomes (9, 22), known as the “Philadelphia chromosome.” In 2016, the World health organization (WHO) introduced a new clinical entity of de novo acute myeloid leukemia (AML). Both diseases share some commonalities, therefore, create a challenge to diagnose.

Carcinosarcomas are aggressive biphasic neoplasms composed of high-grade, malignant, epithelial, and mesenchymal elements. They usually occur in the uterus and rarely involve the ovaries. Only 10% of them are bilateral. Their diagnosis relies on histological examination coupled with immunohistochemistry.

Objective: To describe the outcome following limb-sparing subtotal hemipelvectomy (iliectomy) in a dog with ilial chondrosarcoma. Animal: A 9.5-year-old female spayed Boxer with grade 2 chondrosarcoma of the ilium Study Design: Case report.

A 92-year-old man presented to the hospital with recurrent hypoglycemia with a chronically raised right hemidiaphragm. A CT thorax-abdomen-pelvis showed a large abdominal mass. A ‘big’ IGF-2 secreting non-islet cell tumour was suspected and confirmed. The patient was treated with low dose prednisolone.

Routine examination of an asymptomatic 40-year-old female patient revealed a right unilateral and unifocal renal mass. The patient underwent a partial nephrectomy, and the renal specimen was sent for histopathologic examination. Molecular testing revealed a heterozygous variant NM_003000.3:c.412G>T, p.(Asp138Tyr), in SDHB gene.

Mixed fibrolamellar hepatocellular carcinoma is a rare liver tumor defined by the presence of both pure fibrolamellar hepatocellular carcinoma and conventional hepatocellular components. It represents up to 25% of cases of fibrolamellar hepatocellular carcinoma, and has been associated with a worse prognosis.

We demonstrate the effectiveness of readministering cetuximab as a salvage chemotherapeutic agent after nivolumab administration to a patient with a recurrence of cervical lymph node metastasis after tongue cancer surgery. We can infer that the immunostimulatory effect of nivolumab and reactivation of cetuximab enhance the antitumor effect of the therapy.

Objectives This article focuses on massive epistaxis and pseudoaneurysm in patients with NPC after radiotherapy and discusses clinically relevant treatment strategies. Design Retrospective the medical data of NPC patients with massive epistaxis after radiotherapy and review the English literature over the past 10 years. Setting Otorhinolaryngology department in the First Affiliated Hospital of Nanchang University. Participants 21 patients with massive epistaxis after radiotherapy for NPC. Main outcome measures Characteristics and related causes of massive epistaxis or pseudoaneurysms were analyzed in terms of the clinical stage of NPC, course of radiotherapy, and affected artery. An analysis was performed on the methods of endovascular interventional treatment of such pseudoaneurysms. Results 19 cases were accompanied with bone destruction of the skull base; 13 cases were found tumor recurrence; 15 cases were in stage III or IV of NPC; 14 cases were combined with pseudoaneurysms. Analysis with the imaging of pseudoaneurysms, we found that the petrous ICA was the most predilection site. There were 11 out of 14 pseudoaneurysms had sentinel hemorrhage in the initial phase. All 14 pseudoaneurysm patients were underwent endovascular interventional therapy, but one died from hemorrhagic shock during the procedure. There were no rebleeding again among other patients. Conclusions Pseudoaneurysm could cause massive epistaxis with high mortality. The formation of a pseudoaneurysm was closely associated with a high carcinoma stage, re-radiotherapy, and local bone destruction and infection. Most cases had sentinel epistaxis. The imaging material prompted that pseudoaneurysm had a predisposition to the petrous part of the ICA, while the preferred therapy was endovascular embolization treatment. Key poits 1.Patients with massive epistaxis mean a single nasal bleeding volume exceeded 100 ml, or cumulative bleeding volume was more than 300 ml. 2.Patients who presented with active oronasal bleeding should be rapidly managed by nasal packing. 3.When there is hemorrhagic shock, patients should undergo endotracheal intubation and blood transfusion before being transferred to the otorhinolaryngology department. 4.CTA and DSA are recommended for patients with massive epistaxis associated with NPC after radiotherapy. 5.Interventional embolization is recommended to patients with pseudoaneurysm.

A 62-year-old otherwise healthy patient was admitted with severe headache for several weeks. Initial imaging studies revealed multiple cystic lesions in both hemispheres. Neuroparasitic infections were considered as primary differential diagnosis. Open biopsy of a right frontal cortical lesion was performed. Pathohistological revealed the diagnosis of cerebral metastasis of adenokarcinoma.

Lipomatous hypertrophy of the interatrial septum (LHIAS) is a benign cardiac tumor. Differential diagnosis of LHIAS consists of atrial masses such as myxomas or lipomas. Herein, we report a 66-year-old male, admitted as a case of severe COVID-19 and was found to have a LHIAS extending to the crista terminalis.

Ceritinib shows efficacy in ALK+ NSCLC patients with BM. However, the disease will inevitably progress over time due to acquired resistance. We now report a case with BM from advanced lung adenocarcinoma with ALK mutations who exhibited a surprising and long-term response to treatment of ceritinib combined with bevacizumab.

The study investigates the case of a total thyroidectomy, where after dissection multiple nodules showed two malignant patterns by immunohistochemistry. Molecular analysis based on DNA methylation profile was used to further inspect the origin of the coexisting neoplasms. We confirmed the presence of malignant skin melanoma involving medullary thyroid cancer.