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Topological electrogustometry and chemogustometry surrogate markers of age-related gustatory decline in humans
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  • Pavlos Pavlidis,
  • Gregor Schittek,
  • Athanasios Saratziotis,
  • Maria Ferfeli,
  • Georgios Kekes,
  • Haralampos Gouveris
Pavlos Pavlidis
General Hospital of Thessaloniki G Papanikolaou

Corresponding Author:[email protected]

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Gregor Schittek
Medical University of Graz
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Athanasios Saratziotis
General University Hospital of Larissa
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Maria Ferfeli
Αpplied Informatics, University of Macedonia, Greece
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Georgios Kekes
Aristotle University of Thessaloniki
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Haralampos Gouveris
Johannes Gutenberg University Hospital Mainz
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Objectives: The primary goal was to evaluate the effect of stimulus-duration on Electrogustometry (EGM) Thrasholds, to evaluate any gender-related influences and compare the above results to those after application of Taste-Strips. Design: Electrogustometry (EGM) thresholds of various stimulus duration (0.5, 1.0, 1.5, and 2.0 s) were measured in 212 non-smokers (age range: 10 – 80 years, divided into 8 age groups) without self-reported gustatory impairment. Furthermore, taste strips chemogustometry measurements in 132 participants were performed. Setting: Tertiary referral medical centre. Participants: 212 non-smokers, divided in 8 age-groups participated in the study. Main outcome measures: EGM-Thresholds and taste-strips, duration of stimuli Results: EGM-thresholds increased progressively with age and with increase in stimulus duration from 0.5 sec up to 2 sec. This pattern was consistent at all 6 anatomic areas, irrespective from gender. In contrast, in chemogustometry no differences related either to age or to gender were found. Conclusions: Age-related electrophysiological and functional gustatory decline can be better documented by EGM than using chemogustometry. This superiority of EGM was not influenced by stimulus duration; nonetheless, stimulus duration should be clearly documented in future quantitative EGM-threshold recordings, given that it may significantly influence EGM amplitude threshold measurements.
16 Apr 2020Submitted to Clinical Otolaryngology
20 Apr 2020Submission Checks Completed
20 Apr 2020Assigned to Editor
11 May 2020Reviewer(s) Assigned
14 Jul 2020Review(s) Completed, Editorial Evaluation Pending
02 Aug 2020Editorial Decision: Revise Major
16 Sep 20201st Revision Received
21 Sep 2020Assigned to Editor
21 Sep 2020Submission Checks Completed
02 Nov 2020Reviewer(s) Assigned
18 Nov 2020Review(s) Completed, Editorial Evaluation Pending
06 Dec 2020Editorial Decision: Revise Major
07 Dec 20202nd Revision Received
10 Dec 2020Assigned to Editor
10 Dec 2020Submission Checks Completed
10 Jan 2021Review(s) Completed, Editorial Evaluation Pending
16 Jan 2021Editorial Decision: Accept