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Laryngeal squamous cell carcinoma variants: clinical and pathological analysis of 110 patients over a 10-year period
  • ibrahim yağcı,
  • Can Doruk,
  • Bora Başaran
ibrahim yağcı
Istanbul Universitesi

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Can Doruk
Istanbul Universitesi Istanbul Tip Fakultesi
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Bora Başaran
Istanbul Universitesi Istanbul Tip Fakultesi
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Objectives: Squamous cell carcinoma(SCC) is the most common laryngeal neoplasm. Squamous cell carcinoma variants (vSCC), on the other hand, show different clinical and pathological features than conventional type. The purpose of this study is to analyze the clinical and pathological findings of vSCC of the larynx. Methods: This retrospective study evaluates 110 patients diagnosed with vSCC in our institution between 2006-2017. Treatment of primary and recurrent diseases was evaluated. Overall survival, disease-specific survival and follow-up times were calculated as months. Difference between preoperative and postoperative pathology reports of surgically treated patients were compared. Results: There were 1497 patients diagnosed with laryngeal malignancy and 110 (7,34%) of these patients were diagnosed with vSCC. The most common pathological subgroup was verrucous carcinoma. The best prognosis was found in verrucous carcinoma and the worst was in spindle cell carcinoma. Overall survival rates was 90% and 54.7%, respectively. A group of patients had a preoperative pathological diagnosis, not vSCC, but conventional SCC with the incidence of 38.5-100% according to the histological subtype. This was most common in acantholytic carcinoma, followed by adenosquamous, basaloid and spindle cell carcinoma, respectively. Conclusions: Spindle cell carcinoma and basaloid type squamous cell carcinoma have the worst prognosis and the highest metastatic potential. Patients diagnosed with these two variants should be followed up more cautiously. It should also be kept in mind that the diagnosis of vSCC can be missed in patients diagnosed only with a small tissue biopsy sample.