Cinnamon Extract Effects on Insulin Resistance, Metabolic Factors, and
Menstrual Cyclicity for Women with Polycystic Ovary Syndrome: A
Systematic review and Meta-Analysis
Abstract
Cinnamon is herbal medicine supposed to improve metabolic disorder of
PCOS. This study investigated the effects of cinnamon extract effect on
insulin resistance, metabolic factors, and menstrual cyclicity for woman
with PCOS. This is systematic review and meta-analysis of randomized
controlled trials (RCTs). We searched the MEDLINE, Cochrane, Google
Scholar, and Pubmed databases to identify relevant studies using
cinnamon extract for PCOS. Five RCTs consisting 206 women were entered
in the meta-analysis. Significant differences in body mass index (mean
difference (MD) = -0.21, 95% CI:-1.80 to 1.38, p=0.79; 143
participants), weight (MD = 1.08, 95% CI: -2.79 to 4.96, p=0.58; 143
participants), insulin resistance (MD = -0.19, 95% CI: -0.54 to 0.15,
p=0.27, 190 participants), fasting blood glucose (MD= -4.8, 95% CI:
-8.04 to -1.57, p=0.004; 143 participants), trygliceride (MD= -10.73,
95%CI: -26.35 to 4.88, p=0.18; 143 participants), LDL-cholesterol
(MD=-3.39, 95% CI: -12.27 to 5.50, p=0.46; 143 participants),
HDL-cholesterol (MD= -27.24 , 95%CI : -32.62 to -21.85, p<
0.00001; 143 participants), total cholesterol (MD= -7.8, 95% CI: -17.48
to 1.89, p=0.11; 143 participants), insulin (MD = -2.20, 95% CI: -4.17
to -0.23, p=0.03; 143 participants), DHEA level (MD = -0.1, 95% CI:
-0.62 to 0.41, p=0.70; 104 participants), and menstrual cyclicity in 6
months (MD= 2.28, 95% CI: 1.83 to 2.73, p< 0.00001; 33
participants) were obtained. Cinnamon can be a potential supplementary
therapy agent for PCOS women as it improves fasting blood glucose,
insulin level, HDL–cholesterol and menstrual cyclicity in PCOS women.