Epidemiology, clinical presentation and respiratory sequelae of severe
Adenoviral Pneumonia (ADVP) in children admitted in a tertiary care
Pediatric Intensive Care Unit (PICU) in Kolkata, India.
Abstract
i.Objective- To describe epidemiological, clinical, biochemical, and
radiological profile of children admitted in PICU of a tertiary care
hospital with severe Adenoviral Pneumonia (ADVP) and respiratory
sequelae among them. ii. Design-This is a single-center, prospective
observational study conducted at the Institute of Child Health iii.
Settings-The study had been done in PICU and General Pediatric ward of
Institute of Child Health a 200 bedded tertiary level 3 Pediatric
Hospital of Kolkata, India. iv. Patient-Children less than 10 years of
age admitted with features of Lower Respiratory Tract
Infection(LRTI)/Pneumonia and became positive for adenovirus by
respiratory sample PCR and needed intensive care at any point of the
disease course during the period of -1st December 2018 to 1st May 2019
and then followed up. v. Interventions-This is a non interventional
study. Standard protocolized treatment of patients with severe
adenoviral pneumonia needing PICU care had been done. vi. Main outcome
measures- Survival , poor prognostic factors and development of
respiratory sequalae. vii. Results-96 cases in total and 33 among them
needed PICU care and had been considered as severe ADVP. Males were in
higher proportion than female and almost all had fever, cough, and
respiratory distress at the time of admission. 67% of patients
presented after one week of appearance of symptoms.24 patients had SPO2
<90% in room air at the time of hospital admission. 29 kids
needed respiratory support beyond simple oxygen therapy. HRCT, done in
most of the kids with recurrent symptoms mostly showed features of Post
Infective Bronchiolitis Obliterans.