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SARS-CoV-2 Re-Infection versus Prolonged Shedding: A Case Series
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  • Erin Nicholson,
  • Vasanthi Avadhanula,
  • Sonia Fragoso,
  • Rachel Stroh,
  • Xunyan Ye,
  • Nanette Bond,
  • Patricia Santarcangelo,
  • John Stroh,
  • Pedro Piedra
Erin Nicholson
Baylor College of Medicine
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Vasanthi Avadhanula
Baylor College of Medicine
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Sonia Fragoso
Baylor College of Medicine
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Rachel Stroh
Baylor College of Medicine
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Xunyan Ye
Baylor College of Medicine
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Nanette Bond
Baylor College of Medicine
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Patricia Santarcangelo
Baylor College of Medicine
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John Stroh
CHI St Luke's Health
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Pedro Piedra
Baylor College of Medicine
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Abstract

Since the start of the SARS-CoV-2 pandemic, it has been difficult to differentiate between SARS-CoV-2 re-infection and prolonged RNA shedding. In this report, we identified patients with positive rtPCR results for SARS-CoV-2 ≥70 days apart. Clinical and laboratory data were collected and criteria were applied to discern whether the presentation was consistent with SARS-CoV-2 re-infection or prolonged viral RNA shedding. Eleven individuals met the initial testing criteria, of which, seven met at least one criteria for re-infection and four were consistent with prolonged RNA shedding. These data demonstrate the need for criteria to differentiate SARS-CoV-2 re-infection from prolonged RNA shedding.

Peer review status:ACCEPTED

30 Apr 2021Submitted to Influenza and other respiratory viruses
03 May 2021Assigned to Editor
03 May 2021Submission Checks Completed
16 May 2021Editorial Decision: Accept