loading page

Prospective study on Prophylactic Micafungin sodium against Invasive Fungal Disease during Neutropenia in Pediatric & Adolescent Patients undergoing Autologous Hematopoietic Stem Cell Transplantation
  • +3
  • Bo Kyung Kim,
  • Jung Yoon Choi,
  • Kyung Taek Hong,
  • Hong Yul An,
  • Hee Young Shin,
  • Hyoung Jin Kang
Bo Kyung Kim
Seoul National University College of Medicine
Author Profile
Jung Yoon Choi
Seoul National University College of Medicine
Author Profile
Kyung Taek Hong
Seoul National University College of Medicine
Author Profile
Hong Yul An
Seoul National University College of Medicine
Author Profile
Hee Young Shin
Seoul National University College of Medicine
Author Profile
Hyoung Jin Kang
Seoul National University College of Medicine
Author Profile

Abstract

Background Invasive fungal diseases (IFDs) increase the mortality rate of patients with neutropenia who receive chemotherapy or have previously undergone hematopoietic stem cell transplantation (HSCT). Micafungin is a broad-spectrum echinocandin, with minimal toxicity and low drug interactions. We therefore investigated the efficacy and safety of prophylactic micafungin in pediatric and adolescent patients who underwent autologous HSCT. Methods This was a phase II, prospective, single-center, open-label, and single-arm study. From November 2011 to February 2017, 125 patients were screened from Seoul National University Children’s Hospital, Korea, and 112 were enrolled. Micafungin was administered intravenously at a dose of 1 mg/kg/day (maximum 50 mg/day) from day 8 of autologous HSCT until neutrophil engraftment. Treatment success was defined as the absence of proven, probable, or possible IFD up to 4 weeks after therapy. Results The study protocol was achieved without premature interruption in 110 patients (98.2%). The reasons interrupting micafungin treatment included early death (n=1) and patient refusal (n=1). Treatment success was achieved in 109 patients (99.1%). Only one patient was diagnosed with probable IFD. No patients were diagnosed with possible or proven IFD. In the full analysis set, 21 patients (18.8%) experienced 22 adverse events (AEs); however, all AEs were classified as “unlikely” related to micafungin. No patient experienced grade IV AEs nor discontinued treatment and none of the deaths were related to micafungin. Conclusions Our study demonstrated that micafungin is a safe and effective option for antifungal prophylaxis in pediatric patients who underwent autologous HSCT, with promising efficacy without significant AEs.

Peer review status:UNDER REVIEW

19 Jul 2021Assigned to Editor
19 Jul 2021Submission Checks Completed
19 Jul 2021Submitted to Pediatric Blood & Cancer
21 Jul 2021Reviewer(s) Assigned