Improvement of Depression in a Patient with Hypothyroidism and
Deiodinase Polymorphism with LT3 Therapy
We report a 54-year-old man with treatment-resistant depression (TRD)
and hypothyroidism who responded to LT3/LT4 combination, rather than LT4
alone. He was able to discontinue all antidepressant medications
eventually. Interestingly, the patient has a DIO2 polymorphism.