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In vivo and in silico screening for antimicrobial compounds from cyanobacteria
  • Selina Lenz,
  • Dorina Strieth,
  • Roland Ulber
Selina Lenz
Technical University Kaiserslautern

Corresponding Author:[email protected]

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Dorina Strieth
Technical University Kaiserslautern
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Roland Ulber
Technical University Kaiserslautern
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Due to the emerging rise of multi-drug resistant bacteria, the discovery of novel antibiotics is of high scientific interest. Through their high chemodiversity of bioactive secondary metabolites, cyanobacteria have proven to be promising microorganisms for the discovery of antibacterial compounds. These aspects make appropriate antibacterial screening approaches for cyanobacteria crucial. Up to date, screenings are mostly carried out using a phenotypic methodology, consisting of cyanobacterial cultivation, extraction, and inhibitory assays. However, the parameters of these methods highly vary within the literature. Therefore, the common choices of parameters and inhibitory assays are summarized in this review. Nevertheless, less frequently used method variants are highlighted, which lead to hits from antimicrobial compounds. In addition to the considerations of phenotypic methods, this review provides an overview of developments in the genome-based screening area, be it in-vivo using PCR technique or in-silico using the recent genome-mining method. Though, up to date these techniques are a lot less applied than phenotypical screening.
15 Sep 2021Submitted to MicrobiologyOpen
17 Sep 2021Submission Checks Completed
17 Sep 2021Assigned to Editor
20 Sep 2021Reviewer(s) Assigned
09 Oct 2021Review(s) Completed, Editorial Evaluation Pending
15 Oct 2021Editorial Decision: Revise Minor
08 Dec 20211st Revision Received
08 Dec 2021Submission Checks Completed
08 Dec 2021Assigned to Editor
08 Dec 2021Review(s) Completed, Editorial Evaluation Pending
08 Dec 2021Reviewer(s) Assigned
11 Jan 2022Editorial Decision: Revise Minor
31 Jan 20222nd Revision Received
01 Feb 2022Submission Checks Completed
01 Feb 2022Assigned to Editor
01 Feb 2022Review(s) Completed, Editorial Evaluation Pending
02 Feb 2022Editorial Decision: Revise Minor
03 Feb 20223rd Revision Received
03 Feb 2022Assigned to Editor
03 Feb 2022Submission Checks Completed
03 Feb 2022Review(s) Completed, Editorial Evaluation Pending
07 Feb 2022Editorial Decision: Accept