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Does early olaparib administration improve prognosis in patients with HER2-negative metastatic breast cancer and BRCA1 and/or BRCA2 pathogenic variants?: Finding from four cases
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  • Haruko Takuwa,
  • Shoko Sasaki,
  • Takahiro Yamada,
  • Megumi Takeuchi
Haruko Takuwa
Mitsubishi Kyoto Hospital

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Shoko Sasaki
Mitsubishi Kyoto Hospital
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Takahiro Yamada
Kyoto University Graduate School of Medicine Faculty of Medicine
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Megumi Takeuchi
Mitsubishi Kyoto Hospital
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Abstract

We herein describe our experience of four patients who had been diagnosed as metastatic breast cancer with BRCA 1/2 pathogenic variants. Prior anthracycline and/or taxane-based therapies needed before administration of PARP inhibitors might be still controversial in terms of patients benefit.