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Functional Consequence and Therapeutic Targeting of Cryptic ALK Fusions (ALK fus ) in Monosomy7 AML
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  • Makia K. Manselle,
  • Rhonda E. Ries,
  • Tiffany Hylkema,
  • Amanda Leonti,
  • Danielle C. Kirkey,
  • Scott Furlan ,
  • Soheil Meshinchi
Makia K. Manselle
Fred Hutchinson Cancer Research Center
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Rhonda E. Ries
Fred Hutchinson Cancer Research Center
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Tiffany Hylkema
Fred Hutchinson Cancer Research Center
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Amanda Leonti
Fred Hutchinson Cancer Research Center
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Danielle C. Kirkey
Fred Hutchinson Cancer Research Center
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Scott Furlan
Fred Hutchinson Cancer Research Center
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Soheil Meshinchi
Fred Hutchinson Cancer Research Center
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Abstract

Acute Myeloid Leukemia (AML) patients have a wide array of cytogenetic and molecular aberrations which can influence response to therapy. Monosomy7 (Mono7) is a rare subset within pediatric AML (prevalence of 4-5%), that is highly associated with poor outcomes. Fusions involving the ALK gene (14.3%) were exclusively identified within this high-risk cohort while absent across all other AML. Given the dismal outcomes of Mono7, we evaluated the use of crizotinib, an FDA-approved tyrosine kinase inhibitor, used to treat patients with ALK fusions. Our findings suggest that crizotinib may serve as a novel therapy for these patients.
01 Sep 2022Submitted to Pediatric Blood & Cancer
01 Sep 2022Assigned to Editor
01 Sep 2022Submission Checks Completed
07 Sep 2022Reviewer(s) Assigned
05 Nov 2021Published in Blood volume 138 issue Supplement 1 on pages 2357-2357. 10.1182/blood-2021-148179