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Colchicine enhances β-adrenoceptor-mediated vasodilation in men with essential hypertension
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  • Thomas Svare Ehlers,
  • Jennifer van der Horst,
  • Sophie Møller,
  • Peter Piil,
  • Lasse Gliemann,
  • Christian Aalkjær,
  • Thomas Qvistgaard Jepps,
  • Ylva Hellsten
Thomas Svare Ehlers
University of Copenhagen Faculty of Science
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Jennifer van der Horst
University of Copenhagen Faculty of Science
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Sophie Møller
University of Copenhagen Faculty of Science
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Peter Piil
University of Copenhagen Faculty of Science
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Lasse Gliemann
University of Copenhagen Faculty of Science
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Christian Aalkjær
Aarhus Universitet
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Thomas Qvistgaard Jepps
University of Copenhagen Faculty of Health and Medical Sciences
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Ylva Hellsten
University of Copenhagen Faculty of Science
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Abstract

Aims: Colchicine treatment has known beneficial effects on cardiovascular health and reduces the incidence of cardiovascular disease. Studies in isolated rodent arteries have shown that colchicine can enhance β-adrenoceptor-mediated vasodilation. In this translational study we examined whether this effect of colchicine was present in humans by conducting a double-blinded, placebo controlled intervention study. Methods and Results : Middle-aged men with essential hypertension were randomly assigned firstly to acute treatment with either 0.5 mg colchicine or placebo, and subsequently re-randomized for 3 weeks of treatment with either colchicine 0.5 mg twice daily (n=16) or placebo (n=15) followed by a washout period of 48-72 h. The vasodilator responses to isoprenaline, acetylcholine and sodium nitroprusside, were determined as well as arterial pressure, arterial compliance and plasma inflammatory markers. Acute colchicine treatment increased isoprenaline- (by 38% for the highest dose) as well as SNP- (by 29% main effect) induced vasodilation, but had no effect on the response to acetylcholine. Conclusion: Three weeks of twice daily treatment of colchicine, followed by a wash-out period, did not induce an accumulated or sustained effect on the β-adrenoceptor response and there was no effect on either arterial pressure, arterial compliance or on the level of measured inflammatory markers. The results provide novel translational evidence for a transient enhancing effect of colchicine on β-adrenoceptor-mediated vasodilation in humans with essential hypertension
21 Sep 2022Submitted to British Journal of Clinical Pharmacology
22 Sep 2022Assigned to Editor
22 Sep 2022Submission Checks Completed
23 Sep 2022Reviewer(s) Assigned