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Role of heterogeneity in dictating tumorigenesis in epithelial tissues
  • Sindhu M.,
  • Medhavi vishwakarna
Sindhu M.
Indian Institute of Science

Corresponding Author:[email protected]

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Medhavi vishwakarna
Indian Institute of Science
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Abstract

Biological systems across various length and time scales are noisy, including tissues. Why are biological tissues inherently chaotic? Does heterogeneity play a role in determining the physiology and pathology of tissues? How do physical and biochemical heterogeneity crosstalk to dictate tissue function? In this review, we begin with a brief primer on heterogeneity in biological tissues. Then, we take examples from recent literature indicating functional relevance of biochemical and physical heterogeneity and discuss the impact of heterogeneity on tissue function and pathology. We take specific examples from studies on epithelial tissues to discuss the potential role of inherent tissue heterogeneity in tumorigenesis.
26 Sep 2022Submitted to Computational and Systems Oncology
27 Sep 2022Submission Checks Completed
27 Sep 2022Assigned to Editor
09 Oct 2022Reviewer(s) Assigned
21 Feb 2023Editorial Decision: Revise Minor
29 Mar 20231st Revision Received
30 Mar 2023Review(s) Completed, Editorial Evaluation Pending
30 Mar 2023Submission Checks Completed
30 Mar 2023Assigned to Editor
07 Apr 2023Editorial Decision: Accept