FTO Gene Polymorphisms Influence Neuroblastoma Susceptibility in Chinese
Children
Abstract
Background Neuroblastoma (NB) is a malignancy of neural crest
cells that typically occurs in children. Single nucleotide polymorphisms
(SNPs) in the fat mass and obesity associated ( FTO) gene, a
well-conserved gene, are related to tumorigenesis. However, there is a
lack of evidence regarding the relationship between FTO gene SNPs
and NB susceptibility. Methods TaqMan assay was performed to
determine associations between FTO gene SNPs and the risk of NB
in 898 patients and 1734 controls from eight medical centers in China.
And stratification analysis was performed to assess the association
between the selected FTO SNPs and NB susceptibility among
different subgroups. Results There was no significant
association between the selected FTO polymorphisms and risk of NB
in both single locus analysis and combined analysis. Conclusion
Our study shows that individuals with retroperitoneal NB and those with
III+IV NB are more likely to present with FTO SNPs than other
patients. Furthermore, participants with FTO rs8047395 GG
genotype were more likely to develop III+IV stage NB than other
participants.