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Establishment of the first Children's Drugs and Therapeutic Committee to ensure evidence-based and cost-effective medical treatment for children
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  • Sara Holst,
  • Camilla Møller,
  • Charlotte Vermehren,
  • Stine Trolle,
  • Bente Hansen,
  • Ann-Britt Kirkedal,
  • Hanne Christensen,
  • Thorkild Jacobsen,
  • Rene Mathiasen,
  • Jon Traerup Andersen,
  • Christina Gade
Sara Holst
Copenhagen University Hospital
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Camilla Møller
Copenhagen University Hospital
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Charlotte Vermehren
Bispebjerg Hospital Klinisk Farmakologisk Afdeling
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Stine Trolle
Copenhagen University Hospital
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Bente Hansen
Copenhagen University Hospital
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Ann-Britt Kirkedal
Copenhagen University Hospital
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Hanne Christensen
Copenhagen University Hospital
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Thorkild Jacobsen
Copenhagen University Hospital
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Rene Mathiasen
Copenhagen University Hospital
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Jon Traerup Andersen
Copenhagen University Hospital
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Christina Gade
Copenhagen University Hospital

Corresponding Author:christina.gade@regionh.dk

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Abstract

Aim The prevalence of undocumented medical treatments among children is a significant issue, as well as many EU countries lack access to newly developed children friendly medicines. Consequently, there is a pressing need for supplementary resources that can facilitate informed decision-making regarding children’s medication. We therefore aim to describe the process of establishing a children’s Drug and Therapeutics Committee (cDTC), as well as the preparing and implementation of recommendations for children in the Capital region of Denmark Method Following the guidelines outlined by the World Health Organization a cDTC was established. Recommendations for pediatric medication practice were constructed from assessments of medication use patterns among children in the Capital Region between 2019 and 2021. The recommendations were meticulously crafted based on evaluation of the current marketing authorization landscape and existing best available evidence. Results In 2019, the Capital Region established the first cDTC supported by expert councils and an editorial board. A total of 2.429 purchase item numbers covering 1.222.846 defined daily doses and 592.088 purchased packages covering 10.200.000 defined daily doses were identified in the secondary and primary sectors, respectively. Three comprehensive lists covering recommendations for newborns and children were published between 2021 and 2020 totaling 331 recommended pharmaceutical products. The recommendations primarily intended for use in the secondary healthcare sector were implemented through the revision of 38 pediatric- and 6 neonatal product ranges throughout Capital region. Conclusion Recommendation lists for children governed by a cDTC provide a rational auxiliary tool that can be immediately implemented in the clinic.
10 May 2023Submitted to British Journal of Clinical Pharmacology
11 May 2023Submission Checks Completed
11 May 2023Assigned to Editor
11 May 2023Review(s) Completed, Editorial Evaluation Pending
18 May 2023Reviewer(s) Assigned
20 Jun 2023Editorial Decision: Revise Major
01 Sep 20231st Revision Received
03 Sep 2023Submission Checks Completed
03 Sep 2023Assigned to Editor
03 Sep 2023Review(s) Completed, Editorial Evaluation Pending
07 Sep 2023Reviewer(s) Assigned