Physical therapy for deficits associated with chemotherapy-induced
peripheral neuropathy in children with cancer: a systematic review
Abstract
Chemotherapy-induced peripheral neuropathy (CIPN) is a frequent and
debilitating side effect seen in children undergoing chemotherapy.
Objective: To synthesize the evidence on physiotherapy for CIPN symptoms
and deficits in children with cancer. Methods: A systematic review was
conducted with the following PICOS approach: children with cancer,
physiotherapy, control group or standard care, and randomized controlled
trials and controlled clinical trials comprising range of motion, muscle
strength, motor function, balance, gait, functional mobility, foot
posture, pain, and adverse events outcomes. Searches were conducted in
five electronic databases, reference lists, grey literature, and
clinical trial websites in May 2023. Results: Nine full-text studies met
the inclusion criteria. Although benefits were seen for some outcomes
related to physical function, evidence is not at a stage to provide
recommendations for clinical practice. Conclusion: Research is needed
that includes CIPN-specific outcome measures to better inform the
incidence, natural progression, and the benefits of physiotherapy
interventions.