Unraveling HPV-Associated Cancer Complexity: From Molecular Insights to
Innovative Therapies
Abstract
Human cervical, vaginal, vulval, penile, anal, and oropharyngeal cancers
are all caused by the human papillomavirus (HPV). This review article
focuses on HPV biology, virus-host interactions, cell transformation,
cancer progression, and its co-infection with HIV, HSV, EBV, and other
bacteria in cancer development. It explores HPV vaccination’s role in
preventing high-risk HPV infections and cancers, emphasizes early
detection and screening methods, discusses emerging strategies like
specialized therapies and immuno-based interventions, and considers
personalized medical care for HPV-linked cancers. Comprehensive coverage
includes HPV-associated cancer epidemiology, regional variations, and
India’s unique challenges. The cumulative efforts of scientists
facilitate groundbreaking approaches toward reducing the adverse
consequences of HPV-related malignancies among people and communities.