Essential Maintenance: All Authorea-powered sites will be offline 9am-10am EDT Tuesday 28 May
and 11pm-1am EDT Tuesday 28-Wednesday 29 May. We apologise for any inconvenience.

loading page

Role of microRNAs in oncogenesis: Insights from computational and systems-level modeling approaches
  • Vinodhini Govindaraj,
  • Sandip Kar
Vinodhini Govindaraj
Indian Institute of Technology Bombay
Author Profile
Sandip Kar
Indian Institute of Technology Bombay

Corresponding Author:[email protected]

Author Profile

Abstract

MicroRNAs (miRNAs) are short (~22 nucleotides) non-coding RNAs that are often intricately integrated into the regulatory networks of various cellular processes and govern the cell fate decision making events associated with oncogenesis by regulating the gene expression through post-transcriptional modifications. miRNAs repress the target genes by either degrading the target mRNA or by inhibiting the process of translation. However, mathematical and computational modeling of miRNA-mediated target gene regulation in various cellular network motifs suggests that miRNAs play a much more complex role in cellular decision-making events. In this review, we give an overview of the quantitative insights obtained from such kind of mathematical modeling of miRNA mediated gene regulation by highlighting the various factors associated with miRNA regulation that are pivotal in diversifying the cell fate decisions related to oncogenesis. Intriguingly, recent experiments suggest that miRNAs can even upregulate the translation of the target protein under certain circumstances, which may lead to more complexities in miRNA-mediated gene regulations. We discussed possible avenues to explore such unusual biological observations related to miRNA’s that can be modeled to get a detailed understanding of the influence of miRNAs in the context of oncogenesis.
30 Dec 2020Submitted to Computational and Systems Oncology
31 Dec 2020Submission Checks Completed
31 Dec 2020Assigned to Editor
31 Dec 2020Reviewer(s) Assigned
28 Jan 2021Review(s) Completed, Editorial Evaluation Pending
09 Feb 2021Editorial Decision: Revise Major
19 Apr 20211st Revision Received
23 Apr 2021Submission Checks Completed
23 Apr 2021Assigned to Editor
23 Apr 2021Review(s) Completed, Editorial Evaluation Pending
23 Apr 2021Reviewer(s) Assigned
19 May 2021Editorial Decision: Revise Minor
06 Jun 20212nd Revision Received
14 Jun 2021Submission Checks Completed
14 Jun 2021Assigned to Editor
14 Jun 2021Review(s) Completed, Editorial Evaluation Pending
14 Jun 2021Editorial Decision: Accept
Jun 2021Published in Computational and Systems Oncology volume 1 issue 2. https://doi.org/10.1002/cso2.1028