Maternal serum cholesterol as predictive factor for
large-for-gestational age newborn in pre-pregnant underweight women
Abstract
Objective: To determine the relationship between lipid profile and risks
of adverse pregnancy outcomes in pre-pregnant underweight women. Design:
This study was part of an ongoing cohort study which Chinese gravidas
delivered from January 2015 to December 2016. Setting: Pre-pregnant body
mass index (pre-BMI) was classified into underweight (<18.5
kg/m2), normal weight (18.5-22.9 kg/m2) and overweight/obesity (≥23
kg/m2). Population: There’re 1203 underweight- women, 3281 normal-weight
women and 1209 overweight women met the criteria. Methods: Data of 6233
women and medical information including lipid concentrations, pregnancy
complications, pregnancy and perinatal outcomes were analyzed. Results:
The proportion of underweight women 19.2% and overweight/obese
women19.4% was similar in South China. Serum TC level of underweight
women was significantly higher than overweight/obese women (p
< 0.001). After adjusting for maternal age, underweight women
with high TC level had significantly higher occurrence of LGA
[OR=2.24, 95%CI (1.08, 4.63)], and lower occurrence of SGA
[OR=0.71, 95%CI (0.59, 0.85)], while there were no significant
associations between TC and LGA or SGA in other groups. Conclusion:
Underweight women with high TC had higher occurrence of LGA, while there
was no association between TC levels and LGA in normal and
overweight/obese women. Thus, we should recommend underweight women to
manage the lipid. Funding: This work was supported by the National
Natural Science Foundation of China (Grant No: 81771606), Shenzhen
Science and Technology Innovation Commission (Grant No:
JCYJ20170817172241688, JCYJ20180228163459314), and Clinical Medical
Project 5010 of Sun Yat-sen University, China (Grant No: 2012004). Key
words: underweight; cholesterol; LGA; overweight;