A correlation between the perineural invasion and the cervical nodal
metastasis in patients with laryngeal carcinoma
Abstract
Aim of the work: to determine whether there is a correlation between the
perineural invasion (PNI) and the cervical nodal metastasis of laryngeal
squamous cell carcinoma (SCC). Material and methods: This study was
conducted on 30 patients who have laryngeal SCC in the period from
December 2019 till September 2020. Surgical resection was performed
followed by histopathological examination to detect the presence of PNI,
which was then correlated to the cervical nodal metastasis. Results:
26.7% (8/30) of our patients had PNI. There was a statistical
significance between PNI and the cervical nodal metastasis (P value =
0.018). Conclusion: PNI is a strong histologic predictor of cervical
nodal metastasis. Keywords: Laryngeal squamous cell carcinoma;
Perineural invasion; nodal metastasis. Key points • Most of the head and
neck cancer patients are pathologically diagnosed squamous cell
carcinoma. • Tumor recurrence causes the vast majority of the
mortalities. • perineural invasion is one of the major factors for
tumour recurrence. • perineural invasion may occur centripetally or as
skip lesions. • perineural invasion is a well-known route of tumor
spread in diverse human malignancies.