Sweet drugs Against Bad Bugs: Naphthoquinone-fused Enediyne Sugar
Polysulfates for Nanomolar Inhibition of Coronavirus
- Xiaohua Huang,
- Jing Miao,
- Hongyu Zheng,
- Zhe Ding,
- Xinyu Yu,
- Jingtao Xu,
- Jiaming Lan,
- Aiguo Hu
Xiaohua Huang
East China University of Science and Technology
Author ProfileJing Miao
Chinese Academy of Sciences Shanghai Institute of Immunity and Infection
Author ProfileHongyu Zheng
East China University of Science and Technology
Author ProfileZhe Ding
Chinese Academy of Sciences Shanghai Institute of Immunity and Infection
Author ProfileJingtao Xu
East China University of Science and Technology
Author ProfileJiaming Lan
Chinese Academy of Sciences Shanghai Institute of Immunity and Infection
Author ProfileAbstract
It has been four years since the emergence of the COVID-19 pandemic, and
the ongoing threat it poses to human health and life un-derscores the
continued need for the development of antiviral medications as a means
of mitigating future viral outbreaks. In this study, we present a novel
class of antiviral compounds known as naphthoquinone-fused enediyne
sugar polysulfates, which have demonstrated efficacy against
coronaviruses by targeting the conserved receptor binding domain on
spike proteins. These compounds induce irreversible damage to the viral
structure, resulting in inhibition of viral infection at nanomolar
concentrations with minimal cytotoxic effects. Notably, the selectivity
index of these compounds exceeds 50,000, suggesting significant
potential for further de-velopment in antiviral therapeutics against
coronavirus.