Many chronic inflammatory diseases share features compatible
with the PHM hypothesis
Features of diverse chronic inflammatory diseases suggest compatibility
with the PHM hypothesis[1]. Briefly, allergy/hypersensitivity to
foods and inhalants is increasingly being found in autoimmune and other
inflammatory diseases. Stress has been found to be associated with the
initiation and exacerbation of many inflammatory diseases. Markers of
chronic stress, such as elevated heart rate and low heart rate
variability, have been associated with numerous diseases and all-cause
mortality. Opportunistic pathogen presence and/or dysbiosis has been
documented in many diseases. Autoantibodies are increasingly being found
in diverse inflammation-related and allergic diseases. More traditional
diets that reduce consumption of ultra-processed foods/beverages (e.g.,
Mediterranean diet) are showing benefit.