Acknowledgments
This research was funded by the National Natural Science Foundation of China (No.81770569 and 81870421) and the Postdoctoral Science Foundation of China (2018M643871). K.S.S., S.Y.M., S.Y.T. and performed the experiments, analyzed the data, and drafted the manuscript; B.L., X.Z., and X.H.Z. were responsible for the clinical data acquisition; M.Z. and Y.S.L. participated in the research design and experiments; and X.M.Z., L.W., and Y.H. contributed to critical revision of the manuscript for important intellectual content.