Endpoints
SimulResp quality was evaluated on accuracy, robustness, repeatability
and reproducibility. Accuracy was evaluated by the ability of SimulResp
to produce physiological values of a healthy child within the normal
range (pH 7.40 +/- 0.5; PaCO2 40 +/- 5 mmHg,
PaO2 90 +/- 10 mmHg; SaO2 97% +/- 3%)
when simulated fictive subjects and reference values when replicated
clinical situations. Robustness, defined as the ability of the SimulResp
prediction to remain stable within time when the conditions remained
stable, was evaluated by comparing the blood gas values of each fictive
patient at a VPCE of 30 minutes, 3 and 24 hours. Repeatability, defined
as the ability of the SimulResp
prediction to remain equal when the simulation is repeated within the
same conditions (the same method, in the same operator with the same
equipment within short intervals of time), was evaluated by comparing
each blood gas values of each simulation for the same patient at a VPCE
of 24 hours. Reproducibility, defined as the ability of the SimulResp
prediction to remain equal when the simulation is repeated for the same
patient but within different conditions (the same method but by a
different operator and equipment) was evaluated by comparing simulation
ran by OF and DB for the same patient at a VPCE of 24 hours.