The PBMC compartment in patients with IN-COL is distinct from that of patients with active UC.
We further explored if changes in the PBMC compartment were similar between patients with IN-COL at the time of colitis and those with active UC. Compared with healthy volunteers, patients with active UC had a high proportion of CD19dimCD27+38highcirculating plasmablasts (19% of B-cells compared with 0%; p<0.01), that was not evident in patients with IN-COL (Figure 5a-b). 55% of the circulating plasmablasts in patients with UC flare were IgA+ as compared with 25% in healthy volunteers (p=0.06). Additional differences in the PBMC compartment between patients with active UC and healthy volunteers are shown in Supplementary Table I.