Mucosal-associated invariant T (MAIT) cells are activated in the gastrointestinal tissue of patients with combination ipilimumab and nivolumab therapy-related colitis in a pathology distinct from ulcerative colitis.
Sarah C. Sasson1* , John J. Zaunders2, Kazi Nahar3, C. Mee Ling Munier4, Benjamin P. Fairfax5,6,7, Anna Olsson-Brown8, Carol Jolly8, Scott A. Read9,10, Golo Ahlenstiel9,11, Umaimainthan Palendira12, Richard A. Scolyer3,13, Matteo S. Carlino3,14, Miranda J. Payne5, Vincent T. F. Cheung1, Tarun Gupta7, Paul Klenerman1,16, Georgina V. Long3,17, Oliver Brain#1,15, Alexander M. Menzies#3,17 and Anthony D. Kelleher#2,4
  1. Translational Gastroenterology Unit and Oxford Biomedical Research Centre, Nuffield Department of Medicine, University of Oxford, United Kingdom
  2. Centre for Applied Medical Research, St Vincent’s Hospital, Sydney, Australia.
  3. Melanoma Institute Australia and The University of Sydney, Sydney, Australia.
  4. The Kirby Institute, University of New South Wales, Sydney, Australia.
  5. Department of Oncology, Churchill Hospital, Oxford, United Kingdom.
  6. Department of Oncology, University of Oxford, United Kingdom.
  7. MRC Weatherall Institute of Molecular Medicine, University of Oxford, United Kingdom.
  8. Department of Oncology, Liverpool Hospital, United Kingdom.
  9. Westmead Institute of Medical Research, Sydney, Australia.
  10. Western Sydney University, Sydney, Australia.
  11. Department of Gastroenterology, Blacktown Hospital, Sydney Australia
  12. Discipline of Infectious Diseases and Immunology, The University of Sydney, Sydney, Australia.
  13. Department of Tissue Pathology and Diagnostic Oncology, Royal Prince Alfred Hospital, Sydney, Australia.
  14. Department of Medical Oncology, Westmead and Blacktown Hospitals, Sydney, Australia.
  15. Department of Gastroenterology, John Radcliffe Hospital, Oxford, United Kingdom.
  16. Peter Medawar Building of Pathogen Research, University of Oxford, United Kingdom.
  17. Department of Medical Oncology, Royal North Shore Hospital and Mater Hospitals, Sydney, Australia.
#These authors supervised this work equally.
*Corresponding Author
Dr Sarah C. Sasson
Translational Gastroenterology Unit
Nuffield Department of Medicine
Level 5, John Radcliffe Hospital
Oxford, United Kingdom
OX3 9DU
p) +44(0) 1865220137
e) sarah.sasson@ndm.ox.ac.uk