Statistics
Differences between groups were determined using the unpaired non-parametric Mann-Whitney test. IN-COL samples at the point of colitis were compared with IN-COL at baseline, IN-NAE on 7-10 weeks treatment were compared with IN-NAE at baseline, and UC flare was compared with healthy volunteers and IN-COL patients a the point of colitis. Categorical data were compared by the non-parametric chi-squared test. Correlation analysis was performed using the non-parametric Spearman’s test. All were performed using SPSS software (IBM, NY, USA). Medians and interquartile ranges are reported throughout. A p value<0.05 was considered statistically significant, where multiple comparisons were performed a Bonferroni correction was made as detailed in individual figure legends.