Authors’ contributions
SCS conceived the study, designed and performed experimental work, analysed the data, completed the literature review and wrote the manuscript. JJZ designed experimental work provided expertise and supervision in flow cytometry and critically reviewed the manuscript. KN reviewed and collated clinical data and facilitated retrieval of stored specimens. CMLM performed experimental work. BPF cared for patients, oversaw translational research and collated clinical data. SD facilitated archiving of clinical samples. AOB cared for patients and oversaw translational research. CJ facilitated archiving and retrieval of clinical samples. SAR facilitated archiving and retrieval of clinical samples.GA cared for patients and oversaw translational research. UP supervised translational research. RAS is the Director of the Melanoma Institute Australia Biobank and provided critical review of the manuscript. MSC conceived and facilitated the collaboration between multiple sites and assisted in study design. MJP cared for patients and oversaw clinical recruitment. VTFC cared for patients, facilitated translational research studies and collated clinical data. TG facilitated translational research studies. PK facilitated collaborations between groups, supervised translational research and critically reviewed the manuscript. GVL cared for patients, supervised translational research and provided critical review of the manuscript. OB cared for patients and is the lead investigator of the gastrointestinal tissue studies. AMM cared for patients, designed the study, supervised translational research and wrote the manuscript. ADK designed the study, funded the experimental work, provided infrastructural support and provided critical review of the manuscript. All authors reviewed and approved the final manuscript.