Mucosal-associated invariant T (MAIT) cells are activated in the
gastrointestinal tissue of patients with combination ipilimumab and
nivolumab therapy-related colitis in a pathology distinct from
ulcerative colitis.
Sarah C. Sasson1* , John J.
Zaunders2, Kazi Nahar3, C. Mee Ling
Munier4, Benjamin P. Fairfax5,6,7,
Anna Olsson-Brown8, Carol Jolly8,
Scott A. Read9,10, Golo
Ahlenstiel9,11, Umaimainthan
Palendira12, Richard A. Scolyer3,13,
Matteo S. Carlino3,14, Miranda J.
Payne5, Vincent T. F. Cheung1, Tarun
Gupta7, Paul Klenerman1,16, Georgina
V. Long3,17, Oliver Brain#1,15,
Alexander M. Menzies#3,17 and Anthony D.
Kelleher#2,4
- Translational Gastroenterology Unit and Oxford Biomedical Research
Centre, Nuffield Department of Medicine, University of Oxford, United
Kingdom
- Centre for Applied Medical Research, St Vincent’s Hospital, Sydney,
Australia.
- Melanoma Institute Australia and The University of Sydney, Sydney,
Australia.
- The Kirby Institute, University of New South Wales, Sydney, Australia.
- Department of Oncology, Churchill Hospital, Oxford, United Kingdom.
- Department of Oncology, University of Oxford, United Kingdom.
- MRC Weatherall Institute of Molecular Medicine, University of Oxford,
United Kingdom.
- Department of Oncology, Liverpool Hospital, United Kingdom.
- Westmead Institute of Medical Research, Sydney, Australia.
- Western Sydney University, Sydney, Australia.
- Department of Gastroenterology, Blacktown Hospital, Sydney Australia
- Discipline of Infectious Diseases and Immunology, The University of
Sydney, Sydney, Australia.
- Department of Tissue Pathology and Diagnostic Oncology, Royal Prince
Alfred Hospital, Sydney, Australia.
- Department of Medical Oncology, Westmead and Blacktown Hospitals,
Sydney, Australia.
- Department of Gastroenterology, John Radcliffe Hospital, Oxford,
United Kingdom.
- Peter Medawar Building of Pathogen Research, University of Oxford,
United Kingdom.
- Department of Medical Oncology, Royal North Shore Hospital and Mater
Hospitals, Sydney, Australia.
#These authors supervised this work equally.
*Corresponding Author
Dr Sarah C. Sasson
Translational Gastroenterology Unit
Nuffield Department of Medicine
Level 5, John Radcliffe Hospital
Oxford, United Kingdom
OX3 9DU
p) +44(0) 1865220137
e) sarah.sasson@ndm.ox.ac.uk