The PBMC compartment in patients with IN-COL is distinct from that
of patients with active UC.
We further explored if changes in the PBMC compartment were similar
between patients with IN-COL at the time of colitis and those with
active UC. Compared with healthy volunteers, patients with active UC had
a high proportion of
CD19dimCD27+38highcirculating plasmablasts (19% of B-cells compared with 0%;
p<0.01), that was not evident in patients with IN-COL (Figure
5a-b). 55% of the circulating plasmablasts in patients with UC flare
were IgA+ as compared with 25% in healthy volunteers
(p=0.06). Additional differences in the PBMC compartment between
patients with active UC and healthy volunteers are shown in
Supplementary Table I.