Strengths and Limitations
Strengths of this review were:Firstly, this was the recent largest study to compare DP with SP among pregnant women with malaria. We included all available published data and according to accepted guidelines35. Besides, this article used a comprehensive search strategy and had two team members independently screen identified studies for eligibility.
The limitations of this study were: Firstly, although the purpose was to be more comprehensive, while due to the lack of search of all the grey literature, some studies might have been missed. Besides, all enrollment women received insecticide-treated bednets36 and some of them were not paucigravidae37, 38, these may may lead to the confounding of conclusions. Since the condition of HIV may essentially eliminate the typical pattern of malaria efficacy39, we only included studies reporting HIV-seronegative pregnant women with malaria. Finally, we just described the proportion of the included adverse effects due to the lack of data.