Strengths and Limitations
Strengths of this review were:Firstly, this was the recent largest
study to compare DP with SP among pregnant women with malaria.
We
included all available published data and according to accepted
guidelines35. Besides, this article used a
comprehensive search strategy and had two team members independently
screen identified studies for eligibility.
The limitations of this study were: Firstly, although the purpose was to
be more comprehensive, while due to the lack of search of all the grey
literature, some studies might have been missed. Besides, all enrollment
women received insecticide-treated bednets36 and some
of them were not
paucigravidae37,
38, these may may lead to the
confounding of conclusions. Since the condition of HIV may essentially
eliminate the typical pattern of malaria
efficacy39, we only
included studies reporting HIV-seronegative pregnant women with malaria.
Finally, we just described the proportion of the included adverse
effects due to the lack of data.