Interpretation
Although two studies compared DP and SP for MIP34, 40, the number of participants was small, which might weaken the conclusions and leaded to the low quality of evidence41. This study had shown IPT-DP-4w was associated with lower risk of malaria during pregnancy, moderate-to-high grade pigment deposition and improvements in birth outcomes19. Therefore, in the subgroup analysis, we divided the IPT-DP into two categories, IPT-DP-4-6w and IPT-DP-8w to get substantially more precise summary results.