Main Results
A total of five studies with 4660 HIV-uninfected pregnant women in area
of high malaria-transmission intensity were included in final synthesis.
Meta-analysis showed dihydroartemisinin-piperaquine for intermittent
preventive treatment resulted in lower rates of placental malaria
(RR=0.50; 95%CI, 0.43–0.59) and infection with malaria parasites at
delivery (RR=0.05; 95%CI, 0.01–0.24). In the subgroup analysis,
dihydroartemisinin-piperaquine for intermittent preventive treatment at
4-6 weeks of administration was associated with a better effect for
infection with malaria parasites at delivery.