Adverse effects
Three studies reported the adverse effects which were insufficient with a quantitative analysis13, 14, 24, one reported 303 maternal and infant serious adverse events13, which were least frequent in DP group. Only two reported the similar adverse effects14, 24. Table 2 presented the characteristics of adverse effects. compared with SP, DP can reduced the risk of abdominal pain, chills, headache, malaise, stillbirth and thrombocytopenia depending on the incidence of per person-year at risk function.