Strengths and Limitations
The strengths of the study are the prospective design, the clinic homogeneity of our population (all with early-onset severe PE), and that all patients were managed per standardized protocols with low variability in care. Additionally, the baseline score-risk we used included de gestational age as a strong predictor of perinatal complications and we tested both angiogenic factors and their ratio. Among the limitations, we acknowledge that nowadays the presence of proteinuria is not mandatory for the definition of PE however at the start of the study it was. Secondly, the relatively small sample size precluded the inclusion of more predictors in the model and the validation of the results. Moreover, the study lacks information on the long-term follow-up of the neonates.