Prediction of epitopes of anti-properdin
Anti-Properdin epitopes were predicted using the IEBD server -
http://tools.iedb.org/bcell/ (Fig. 4A). The majority of the
binding epitopes were outside of the “vertex”, formed at the junction
of two monomers and responsible for the convertase binding. They were
located in the linker regions between different “vertexes”. The
predicted peptide antigenic determinants of a molecule of prorperdin
with a size greater than 3 amino acid residues are presented in Table 3.