Cladribine (0.1 µM) decreases the granularity of LPS-stimulated microglia
The size and granularity of naïve and LPS-stimulated microglia treated with CdA were investigated by flow cytometry (Figure 2 ). LPS stimulation increased the SSC mean fluorescent intensity (MFI) indicating increased cellular granularity (Figure 2A and B ). We observed a trend towards reduced granularity of LPS-stimulated microglia treated with 0.1 µM CdA (p=0.07), while CdA did not influence the granularity of naïve microglia (Figure 2A and B ). No apparent difference in cell size reflected by FSC MFI was observed (Figure 2A and C ).