Introduction
Eosinophilic gastroenteritis (EG) is a rare chronic inflammatory disease characterized by eosinophilic infiltration that may involve any part of the gastrointestinal (GI) tract wall with various manifestations [1,2]. Although no accurate epidemiologic data are available, the incidence of EG is estimated to be approximately 1-30/100,000 [3,4]. The stomach and small intestine are the most commonly affected areas. Based on the histopathological findings of eosinophilic infiltration, it can be divided into three types: mucosal, muscularis and subserosal [5]. Clinical manifestations vary greatly, depending on which layer and part of the GI tract are predominantly affected. Patients with the mucosal form mostly present with abdominal pain, vomiting, diarrhea, anemia, and protein-losing enteropathy. Obstructive symptoms are typical symptoms of the muscularis form, while the symptoms of the serosal forms may include ascites, bloating, possible peritonitis, and a high peripheral eosinophil count [6]. Due to its rarity and unspecific presentations, EG is not only easy to ignore in clinical practice, but also easy to miss in the process of pathological diagnosis [7], leading to misdiagnosis. Here, we present an EG case misdiagnosed as cholelithiasis and discuss its clinical characteristics. This can illustrate the importance of including EG in the differential diagnosis of abdominal pain even when there are no obvious allergens that suggest it as a possible reason.