AUTHOR CONTRIBUTIONS
A.K.K., S.S., S.M. and S.R. conducted the electrophysiological experiments in Xenopus oocytes, supervised by N.D.. A.d.l.C. and D.A.P. conducted the electrophysiological experiments in HEK-293 cells, supervised by C.V. and T.G.. M.B., D.R., J.C.E.M.M. and B.A.A.R. generated the in-silico data, supervised by W.G.. S.M. and S.R. generated the mutants. A.K.K., and S.M. analyzed electrophysiological data. A.K.K. performed statistical analyses, generated the figures and contributed to the manuscript writing. N.D., W.G., T.G. and C.V. conceived and designed the experiments. N.D. supervised the whole project and wrote the manuscript.