Outcomes
There are currently no validated core outcome sets for twin pregnancy
research, thus outcomes were based on: existing literature, discussion
with representatives from the Multiple Births Foundation and the Twins
Trust, and limitations noted from systematic reviews5,
7.
- Incidence of sIUFD after 14 weeks gestation in MC twin pregnancies.
- Complications associated with sIUFD: rates of sIUFD associated with
antenatal complications (TTTS, sIUGR and congenital/structural
anomalies), management of antenatal complications, rate of spontaneous
sIUFDs
- Surviving co-twin outcomes: perinatal mortality (miscarriage defined
as fetal death <24 weeks, and stillbirth fetal death
>24 weeks), antenatal CNS imaging, gestation at delivery
(if preterm <37 weeks, <34 weeks, <28
weeks, iatrogenic or spontaneous), role of induction, mode of delivery
and reason if not normal vaginal delivery, post-mortem findings.
- Neonatal outcomes: neonatal death defined as at least until discharge,
neonatal intensive care unit admission and reason, postnatal CNS
imaging, abnormal neurological signs in the neonatal period.
- Maternal outcomes: major maternal morbidity, as reported by UKOSS
studies17.