Case 1 Case 2 Case 3
Age (yrs)/sex 82/female 89/female 67/male
DPP4-inhibitors
linagliptin→ teneligliptin sitagliptin→ vildagliptin
alogliptin
Other drugs metformin 250mg amlodipine 5mg metoformin 500mg
miglitol 75mg candesartan 1mg
amlodipine 5mg
candesartan 4mg
loxoprofen 60mg
etizolam 0.5mg
Diabetic retinopathy none none none
eGFR (ml/min/1.73m2)/UAE (mg/gCr) 50.6/ - 60.5/ - 57.2/ 3.0
Comorbidity
Hypertension, cerebral infarction, intestinal obstruction
Hypertension
Gastric ulcer, Hypertension, Gallstones
Period of DPP-4 inhibitors administration until onset of BP
16 months
38 months
6 months
anti-BP180 autoantibody 328 U/mL 3450 U/mL
erythema / blisters +/+ +/+ +/+
Eosinophil infiltration mild severe mild
Relapse
HLA(DQB1*03:01) not examined
Therapy for BP
prednisolone, minocycline, cyclosporine, Steroid pulse therapy, intravenous immunoglobulin therapy prednisolone, tetracycline, cyclosporine, niceritrol prednisolone, tetracycline, niceritrol, nicotinamide
Outcomes/ Cause Death Acute subdural hematoma Death Pulmonary metastasis?
Remission