↓ number |
Congenital or acquired immunodeficiency (AIDS included) |
Higher incidence of cancers and infections |
(Whiteside & Herberman,
1994) |
|
Fanconi’s anaemia (bone marrow impairment) |
Multiple infections |
(Orange, 2013) |
|
Autosomal recessive SCID |
Multiple infections |
(Orange,
2013) |
↓ activity |
Chediak-Higashi syndrome (abnormal lytic granule
biogenesis) |
Increased risk for lymphoma |
(Orange, 2013; Whiteside &
Herberman, 1994) |
|
Griscelli syndrome type 2 (lytic granules do not detach from
microtubules) |
Susceptibility to bacterial and herpesvirus infection |
(Orange, 2013) |
|
Wiskott-Aldrich syndrome (defective actin organization at immune
synapse) |
Multiple infections, susceptibility to herpes virus |
(Orange
et al., 2002) |
|
Hermansky-Pudlak syndrome (abnormal lytic granule biogenesis) |
Susceptibility to bacterial and herpesvirus infection |
(Badolato et
al., 2012) |
↑ number or
↑ activity
|
unknown |
Recurrent spontaneous abortion |
(Perricone et al., 2007) |
|
Acute large granular lymphocyte proliferation |
Aggressive
leukaemia/lymphoma |
(Whiteside & Herberman, 1994) |
|
Chronic NK cell lymphocytosis |
Vasculitis, arthritis and peripheral
neuropathy |
(Fogel, Yokoyama & French, 2013) |