Introduction
According to the World Health Organization (WHO) coronavirus disease 2019 (Covid-19) as a public health emergency is an international concern1, First identified in Wuhan, China, it can spread rapidly with a wide spectrum of severity 2. There are various clinical features in COVID-19, ranging from asymptomatic state to multi organ dysfunction and acute respiratory distress syndrome 3. The typical symptoms include cough, fever, headache, sore throat, myalgia, fatigue, breathlessness, and conjunctivitis in some cases4 . Thus, it is hardly distinguishable from other respiratory infections. By the end of the first week, COVID-19 can lead to pneumonia, respiratory failure, and death 5. About 66.6% of the patients had cough, but only 44.7% of whom had a fever. Also, the sputum production was observed in one-third of patients and sore throat was found in 14.0%, Less than 5% of patients had gastrointestinal symptoms, such as nausea, diarrhea, and vomiting 4. Fever and cough were the most common symptoms among patients with pneumonia caused by COVID-196.In one of the first reports on the disease, Huang et al. showed that the patients had dry cough, fever, dyspnea and malaise7.A suspect case is defined as a person with symptoms including cough sore throat and fever, who had travelled to China or other areas of local persistent transmission and had physical contacts with confirmed COVID-19 infection patients6. The cases may be asymptomatic or even without fever 8,9. A confirmed case is a suspect case with a positive molecular test8. Nonetheless, we visited two cases in Modarres hospital clinic with naso-pharyngeal sputum who had no history of sinusitis as the first symptom.
We presented two patients infected with COVID-19 were followed with RT-PCR testing of throat swabs from Tehran, IRAN.