1 | INTRODUCTION
Uterine cervical cancer (UCC) is a common cancer that causes
>311,000 deaths worldwide each year1.
Advances in radiotherapy and chemotherapy have markedly improved the
treatment outcomes of UCC 2. Translational research
efforts have provided information on the biological properties of tumors
associated with treatment responses in patients with
UCC3–5, which may help to personalize treatment
strategies.
Although UCC is a common cancer, a subset that produces
granulocyte-colony stimulating factor (G-CSF) is rare. G-CSF-producing
UCCs are highly aggressive6–13. However, specific
patterns of care for G-CSF-producing UCCs have not been established, and
treatment outcomes remain unknown because of the limited number of
reported cases. Moreover, the mutation profile of G-CSF-producing UCC
has not been analyzed. Here, we report a case of G-CSF-producing UCC,
and the results of mutational analysis and literature review.