References
1. Brignole M, Moya A, de Lange FJ, Deharo JC, Elliott PM, Fanciulli A,
Fedorowski A, Furlan R, Kenny RA, Martín A, et al; ESC Scientific
Document Group. 2018 ESC Guidelines for the diagnosis and management of
syncope. Eur Heart J. 2018;39:1883–1948.
2. Alboni P, Holz A, Brignole M. Vagally mediated atrioventricular
block: pathophysiology and diagnosis. Heart. 2013;99:904–908.
3. Sandhu RK, Raj SR, Thiruganasambandamoorthy V, Kaul P, Morillo CA,
Krahn AD, Guzman JC, Sheldon RS; Secondary Writing Committee, Banijamali
HS, MacIntyre C, Manlucu J, Seifer C, Sivilotti M. Canadian
Cardiovascular Society Clinical Practice Update on the Assessment and
Management of Syncope. Can J Cardiol 2020 Aug;36(8):1167-1177
4. Sheldon R, Faris P, Tang A, Ayala-Paredes F, Guzman J, Marquez M,
Morillo CA, Krahn AD, Kus T, Ritchie D, Safdar S, Maxey C, Raj SR; POST
4 investigators. Midodrine for the Prevention of Vasovagal Syncope : A
Randomized Clinical Trial. Ann Intern Med. 2021 Oct;174(10):1349-1356.
5. Aksu T, Gopinathannair R, Gupta D, Pauza DH. Intrinsic cardiac
autonomic nervous system: What do clinical electrophysiologists need to
know about the ”heart brain”? J Cardiovasc Electrophysiol. 2021
Jun;32(6):1737-1747.
6. Armour JA, Murphy DA, Yuan BX, Macdonald S, Hopkins DA. Gross and
microscopic anatomy of the human intrinsic cardiac nervous system. Anat
Rec. 1997;247:289‐298.
7. Ulphani JS, Arora R, Cain JH, et al. The ligament of Marshall as a
parasympathetic conduit. Am J Physiol Heart Circ Physiol. 2007;293:
H1629‐H1635.
8. Writing Committee Members, Shen WK, Sheldon RS, Benditt DG, Cohen MI,
Forman DE, Goldberger ZD, Grubb BP, Hamdan MH, Krahn AD, Link MS,
Olshansky B, Raj SR, Sandhu RK, Sorajja D, Sun BC, Yancy CW. 2017
ACC/AHA/HRS guideline for the evaluation and management of patients with
syncope: A report of the American College of Cardiology/American Heart
Association Task Force on Clinical Practice Guidelines and the Heart
Rhythm Society. Heart Rhythm. 2017 Aug;14(8):e155-e217.
9. Pachon JC, Pachon EI, Cunha Pachon MZ, Lobo TJ, Pachon JC, Santillana
TG. Catheter ablation of severe neurally meditated reflex
(neurocardiogenic or vasovagal) syncope: cardioneuroablation long-term
results. Europace. 2011;13:1231–1242.
10. Hu F, Zheng L, Liang E, Ding L, Wu L, Chen G, Fan X, Yao Y. Right
anterior ganglionated plexus: the primary target of cardioneuroablation?
Heart Rhythm. 2019;16:1545–1551.
11. Aksu T, Guler TE, Bozyel S, Yalin K, Gopinathannair R. Usefulness of
post-procedural heart rate response to predict syncope recurrence or
positive head up tilt table testing after cardioneuroablation. Europace.
2020;22:1320–1327.
12. Aksu Tolga, Guler Tumer E, Saygı Serkan, Yalin Kivanc. Usage of
implantable loop recorder to evaluate absolute effectiveness of
cardioneuroablation. J. Cardiovasc. Electrophysiol. 2019 Dec;30
(12):2986–2987.
13. Parry SW, Reeve P, Lawson J, Shaw FE, Davison J, Norton M, Frearson
R, Kerr S, Newton JL. The Newcastle protocols 2008: an update on head-up
tilt table testing and the management of vasovagal syncope and related
disorders. Heart. 2009 Mar; 95(5):416-20.
14. Kusumoto FM, Schoenfeld MH, Barrett C, Edgerton JR, Ellenbogen KA,
Gold MR, Goldschlager NF, Hamilton RM, Joglar JA, Kim RJ, et al. 2018
ACC/AHA/HRS guideline on the evaluation and management of patients with
bradycardia and cardiac conduction delay: a report of the American
College of Cardiology/American Heart Association Task Force on Clinical
Practice Guidelines and the Heart Rhythm Society. Circulation.
2019;140:e382–e482.
15. Aksu T, Güler TE, Yalın K. Step-by-Step Cardioneuroablation Approach
in Two Patients with Functional Atrioventricular Block. Balkan Med J.
2019 Oct 28;36(6):301-310.
16. Aksu T, Guler TE, Bozyel S, Yalin K. Potential usage of
cardioneuroablation in vagally mediated functional atrioventricular
block. SAGE Open Med. 2019 Mar 15;7:2050312119836308.
17. Aksu T, Gopinathannair R, Bozyel S, Yalin K, Gupta D.
Cardioneuroablation for Treatment of Atrioventricular Block. Circ
Arrhythm Electrophysiol. 2021 Sep;14(9):e010018.
18. Aksu T, Yalin K, John L, Osorio J, Winterfield J, Aras D,
Gopinathannair R. Effect of conscious sedation and deep sedation on the
vagal response characteristics during ganglionated plexus ablation. J
Cardiovasc Electrophysiol. 2021 Aug;32(8):2333-2336.
19. Neukirchen M, Kienbaum P. Sympathetic nervous system: evaluation and
importance for clinical general anesthesia. Anesthesiology. 2008
Dec;109(6):1113-31.
20. Aksu T, Baysal E, Lakkireddy D, Yalin K, Gopinathannair R.
Comparison of Fragmented Electrogram Based Strategy and High Frequency
Stimulation for Detection of Ganglionated Plexi. J Atr Fibrillation.
2020 Dec 31;13(4):2440.
21. Lellouche N, Buch E, Celigoj A, et al. Functional characterization
of atrial electrograms in sinus rhythm delineates sites of
parasympathetic innervation inpatients with paroxysmal atrial
fibrillation. J Am Coll Cardiol. 2007;50:1324‐1331.
22. Aksu T, Golcuk E, Yalin K, Guler TE, Erden I. Simplified
cardioneuroablation in the treatment of reflex syncope, functional AV
block, and ainus node dysfunction. Pacing Clin Electrophysiol. 2016;
39:42–53.
23. Pachon MJC, Pachon MEI, Pachon MJC, et al. A new treatment for
atrial fibrillation based on spectral analysis to guide the catheter
RF‐ablation. Europace. 2004;6:590‐601.
24. Aksu T, Guler TE, Mutluer FO, Bozyel S, Golcuk SE, Yalin K.
Electroanatomic‐mapping guided cardioneuroablation versus combined
approach for vasovagal syncope: a crosssectional observational study. J
Interv Card Electrophysiol. 2019;54:177‐188.
25. Aksu T, Yalin K, Bozyel S, Gopinathannair R, Gupta D. The anatomical
basis behind the neuromodulation effects associated with pulmonary vein
isolation. J Cardiovasc Electrophysiol. 2021 Jun;32(6):1733-1736.
26. Aksu T, Guler TE, Bozyel S, Yalin K. Vagal responses during
cardioneuroablation on different ganglionated plexi: is there any role
of ablation strategy? Int J Cardiol. 2019;304:50–5.
27. Pauziene N, Pauza DH, Stropus R. Morphology of human intracardiac
nerves: an electron microscope study. J Anat. 2000;197:437‐459.
28. Saburkina I, Rysevaite K, Pauziene N, et al. Epicardial neural
ganglionated plexus of ovine heart: anatomic basis for experimental
cardiac electrophysiology and nerve protective cardiac surgery. Heart
Rhythm. 2010;7:942‐950.
29. Aksu T, De Potter T, John L, Osorio J, Singh D, Alyesh D, Baysal E,
Kumar K, Mikaeili J, Dal Forno A, Yalin K, Akdemir B, Woods CE, Salcedo
J, Eftekharzadeh M, Akgun T, Sundaram S, Aras D, Tzou WS, Gopinathannair
R, Winterfield J, Gupta D, Davila A. Procedural and short-term results
of electroanatomic-mapping-guided ganglionated plexus ablation by
first-time operators: A multicenter study. J Cardiovasc Electrophysiol.
2022 Jan;33(1):117-122.
30. Aksu T, Guler TE. Electroanatomical mapping-guided ablation during
atrial fibrillation: a novel usage of fractionation mapping in a case
with sinus bradycardia and paroxysmal atrial fibrillation. J Interv Card
Electrophysiol. 2020 Mar;57(2):331-332.
31. Aksu T, Yalin K, Gopinathannair R. Fractionation mapping software to
map ganglionated plexus sites during sinus rhythm. J Cardiovasc
Electrophysiol. 2020 Dec;31(12):3326-3329.
32. Osorio J, Doud DM, Aksu T. Fractionation Mapping by Using a
High-density Catheter to Map Ganglionated Plexus Sites During Sinus
Rhythm. J Innov Card Rhythm Manag. 2021 Jan 15;12(Suppl 1):7-8.
33. John LA, Mullis A, Payne J, Tung R, Aksu T, Winterfield JR.
Cardioneuroablation for cardioinhibitory vasovagal syncope. J Cardiovasc
Electrophysiol. 2021 Jun;32(6):1748-1753.
34. Pachon MJC, Pachon MEI, Santillana PTG, Lobo TJ, Pachon CTC, Pachon
MJC, et al. Simplified method for vagal effect evaluation in J Interv
Card Electrophysiol cardiac ablation and electrophysiological
procedures. JACC Clin Electrophysiol. 2015;1:451–60.
35. Jungen C, Scherschel K, Eickholt C, et al. Disruption of cardiac
cholinergic neurons enhances susceptibility to ventricular arrhythmias.
Nat Commun. 2017;8:14155.