The association between LILRA3 gene polymorphism and the development of IBD
The deletion rate among 877 subjects enrolled in our study (both patients and healthy controls) was 89.4%, which was higher in comparison with that reported for the Han Chinese population in Beijing (CHB) (89.4% vs. 70%)[30]. The deletion ratio in three groups was 88.4% for healthy controls, 91.4% for CD and 90.7% for UC, and no association was found between the 6.7-kb deletion and IBD development (p=0.27, pFDR=0.41, OR=1.39, 95%CI=0.78-2.47 for CD; p=0.39, pFDR=0.96, OR=1.28, 95%CI=0.73-2.22 for UC). In addition, no difference at the allele level (“-” vs. “+”) was found (p=0.70, pFDR=0.90, OR=1.05, 95%CI=0.82-1.35 for CD; p=0.87, pFDR=0.87, OR=1.02, 95%CI=0.80-1.30 for UC) (Table 1), and the deletion did not affect the phenotype frequencies of CD or UC (Table 2). These data indicate that the 6.7-kb deletion has no association with CD and UC development among the Han population of Central China.
Limited association was detected between the rs103294 and rs410852 genotypes and disease susceptibility. (p=0.94 for rs103294; p=0.17 for rs410852). Nonetheless, at the allele level, the allele T of rs103294 was found to be a risk locus for CD (p=0.04, pFDR=0.12, OR=1.32, 95%CI=1.01-1.73) (Table 1). Relationships between the phenotypes of patient groups and the controls were then analyzed, revealing that the CD patients carrying the rs410852 genotype were less likely to develop intestinal stricturing or penetrating complications (Table 2). However, no association for the genotypes and allele frequencies between the UC patients and controls was observed for the groups as a whole or after stratified.