A schematic of the possible signaling pathway for LILRA3
The exact receptor for LILRA3 remains unknown. The classical human
leukocyte antigen-І (HLA-І): HLA-C and the non-classical HLA-І
molecule HLA-G as well as Nogo 66 (a highly conserved
66-amino acid loop of Nogo A ) are reported as possible receptors
for LILRA3[22,33,34]. Based on these findings, we
hypothesize that LILRA3 might activate the above
signaling pathway by interacting
with one of the above or unknown receptors (Figure 7).