Phenotype 6.7 kb deletion 6.7 kb deletion 6.7 kb deletion 6.7 kb deletion rs103294 rs103294 rs103294 rs103294 rs103294 rs103294 rs410852 rs410852 rs410852 rs410852 rs410852 rs410852 rs410852 rs410852
-/-,-/+ VS +/+ -/-,-/+ VS +/+ P OR(95%CI) TT,CT VS CC TT,CT VS CC P P OR(95%CI) OR(95%CI) GG,AG VS AA GG,AG VS AA GG,AG VS AA P P OR(95%CI) OR(95%CI)
dHC (N) 450 59 Ref Ref 453 56 56 Ref Ref Ref Ref 495 14 14 Ref Ref Ref
CD (N) 169 16 165 20 20 176 9 9
Diagnosis age e(yr) <17
13
2
1.00
0.79(0.19-3.87)
12
2
2
1.00
1.00
0.74(0.16-3.40)
0.74(0.16-3.40)
14
0
0
1.00
1.00
1.03(1.01-1.04)
17-40 122 10 1.60(0.80-3.22) 113 13 13 0.83 0.83 1.08(0.57-2.03) 1.08(0.57-2.03) 120 6 6 0.38 0.38 0.57(0.21-1.50)
>40 34 4 1.00 1.11(0.38-3.25) 40 5 5 1.00 1.00 0.99(0.38-2.61) 0.99(0.38-2.61) 42 3 3 0.31 0.31 0.40(0.11-1.43)
Site of disease
L1 Ileal L2 Colonic L3 Ileocolitis L4 Upper fGI 45 51 69 4 3 8 5 0 0.26 0.66 0.21 1.00 1.97(0.59-6.53) 0.84(0.38-1.85) 1.81(0.70-4.67) 1.13(1.10-1.17) 43 51 67 4 5 8 7 0 5 8 7 0 0.90 0.56 0.69 1.00 0.90 0.56 0.69 1.00 1.06(0.40-2.80) 0.79(0.36-1.75) 1.18(0.52-2.70) 1.12(1.09-1.16) 1.06(0.40-2.80) 0.79(0.36-1.75) 1.18(0.52-2.70) 1.12(1.09-1.16) 45 56 71 4 3 3 3 0 3 3 3 0 0.36 0.55 0.80 1.00 0.36 0.55 0.80 1.00 0.42(0.12-1.53) 0.53(0.15-1.89) 0.67(0.19-2.39) 1.03(1.01-1.04)
Disease behavior
B1 Non-stricturing/ Non-penetrating B2 Stricturing B3 Penetrating Perianal disease UC (N) 114 33 22 26 175 11 4 1 1 18 0.37 1.00 0.46 0.34 1.36(0.69-2.67) 1.08(0.37-3.16) 2.88(0.38-21.79) 3.41(0.45-25.59) 113 31 21 25 172 12 6 2 2 21 12 6 2 2 21 0.65 0.49 0.99 0.79 0.65 0.49 0.99 0.79 1.16(0.60-2.25) 0.64(0.26-1.60) 1.30(0.30-5.68) 1.55(0.36-6.70) 1.16(0.60-2.25) 0.64(0.26-1.60) 1.30(0.30-5.68) 1.55(0.36-6.70) 122 33 21 26 187 3 4 3 1 6 3 4 3 1 6 1.00 0.03 0.04 0.54 1.00 0.03 0.04 0.54 1.12(0.33-4.07) 0.23(0.07-0.75) 0.20(0.05-0.74) 0.74(0.09-5.81)
Diagnosis age (yr) <17 17-40 >40 Disease location E1 Proctitis E2 Left-sided E3 Extensive 3 96 76 19 70 86 0 8 10 4 8 6 1.00 0.25 0.99 0.61 0.73 0.15 1.13(1.10-1.17) 1.57(0.73-3.40) 1.00(0.49-2.03) 0.62(0.21-1.89) 1.15(0.53-2.50) 1.88(0.79-4.49) 22 73 77 19 68 85 0 10 11 4 10 7 0 10 11 4 10 7 0.20 0.78 0.68 0.54 0.64 0.33 0.20 0.78 0.68 0.54 0.64 0.33 1.12 (1.09-1.16) 0.90 (0.44-1.85) 0.87 (0.43-1.73) 0.59 (0.19-1.79) 0.84 (0.41-1.73) 1.50 (0.62-3.41) 1.12 (1.09-1.16) 0.90 (0.44-1.85) 0.87 (0.43-1.73) 0.59 (0.19-1.79) 0.84 (0.41-1.73) 1.50 (0.62-3.41) 2 101 84 22 76 89 0 2 4 1 2 3 0 2 4 1 2 3 1.00 0.90 0.57 0.49 1.00 1.00 1.00 0.90 0.57 0.49 1.00 1.00 1.03 (1.01-1.04) 1.43 (0.32-6.38) 0.59 (0.19-1.85) 0.62 (0.08-4.95) 1.08 (0.24-4.82) 0.84 (0.24-2.98)