A schematic of the possible signaling pathway for LILRA3
The exact receptor for LILRA3 remains unknown. The classical human leukocyte antigen-І (HLA-І): HLA-C and the non-classical HLA-І molecule HLA-G as well as Nogo 66 (a highly conserved 66-amino acid loop of Nogo A ) are reported as possible receptors for LILRA3[22,33,34]. Based on these findings, we hypothesize that LILRA3 might activate the above signaling pathway by interacting with one of the above or unknown receptors (Figure 7).