The association between LILRA3 gene polymorphism and the
development of IBD
The deletion rate among 877 subjects enrolled in our study (both
patients and healthy controls) was 89.4%, which was higher in
comparison with that reported for the Han Chinese population in Beijing
(CHB) (89.4% vs. 70%)[30]. The deletion
ratio in three groups was 88.4% for healthy controls, 91.4% for CD and
90.7% for UC, and no association was found between the 6.7-kb deletion
and IBD development (p=0.27, pFDR=0.41, OR=1.39,
95%CI=0.78-2.47 for CD; p=0.39, pFDR=0.96, OR=1.28,
95%CI=0.73-2.22 for UC). In addition, no difference at the allele level
(“-” vs. “+”) was found (p=0.70, pFDR=0.90,
OR=1.05, 95%CI=0.82-1.35 for CD; p=0.87, pFDR=0.87,
OR=1.02, 95%CI=0.80-1.30 for UC) (Table 1), and the deletion did not
affect the phenotype frequencies of CD or UC (Table 2). These data
indicate that the 6.7-kb deletion has no association with CD and UC
development among the Han population of Central China.
Limited association was detected between the rs103294 and rs410852
genotypes and disease susceptibility. (p=0.94 for rs103294; p=0.17 for
rs410852). Nonetheless, at the allele level, the allele T of rs103294
was found to be a risk locus for CD (p=0.04, pFDR=0.12,
OR=1.32, 95%CI=1.01-1.73) (Table 1). Relationships between the
phenotypes of patient groups and the controls were then analyzed,
revealing that the CD patients carrying the rs410852 genotype were less
likely to develop intestinal stricturing or penetrating complications
(Table 2). However, no association for the genotypes and allele
frequencies between the UC patients and controls was observed for the
groups as a whole or after stratified.