rs103294 and rs410852 genotyping
The genotypes of rs103294 and rs410852 were detected by the PCR-ligation detection reaction (PCR-LDR) method with technical support from Shanghai Biowing Applied Biotechnology Company (Shanghai, China)[28,29]. The sequences of the primers and probes are listed in Supplementary Table 2. The PCR product was used as the template in the LDR reaction, and the LDR products were assessed using the ABI 3730 sequencer (ABI, Carlsbad, USA).