Emergence of cumulative mutations SARS-CoV-2 S
glycoprotein
Analysis of the S glycoprotein sequences of SARS-CoV-2 showed that
several isolates have rapidly accumulated multiple mutations. Isolate
Beijing_IVDC-BJ-005_2020 from
China was found to contain substitutions V860C, L861K, and F970S. While
isolate Belgium_BA-02291_2020 from Belgium contained substitutions
K458R, H519P, D614G, T941A, and S943P. Further analysis also revealed 51
different isolates from Belgium (Supplementary Figure 4) had the
D614G and S943P substitutions,
indicating that Belgium_BA-02291_2020 most likely evolved from these
isolates. The number of isolates that had accumulated 2 mutations from
around the world was found to be 30.