Emergence of cumulative mutations SARS-CoV-2 S glycoprotein
Analysis of the S glycoprotein sequences of SARS-CoV-2 showed that several isolates have rapidly accumulated multiple mutations. Isolate Beijing_IVDC-BJ-005_2020 from China was found to contain substitutions V860C, L861K, and F970S. While isolate Belgium_BA-02291_2020 from Belgium contained substitutions K458R, H519P, D614G, T941A, and S943P. Further analysis also revealed 51 different isolates from Belgium (Supplementary Figure 4) had the D614G and S943P substitutions, indicating that Belgium_BA-02291_2020 most likely evolved from these isolates. The number of isolates that had accumulated 2 mutations from around the world was found to be 30.