Figure 1. Diagrammatic representation highlighting the
peak of cytokines and immune responses involved in the cytokine
release storm (CRS) of COVID-19 . Peak detrimental inflammatory
mediators (red) and beneficial adaptive immune response against viral
infections (green) are shown during a 24 h time period. The dotted line
and the red clock indicate the period between 4:00 pm and midnight in
which the detrimental effects of CRS outweighs the beneficial effect of
the adaptive immune response. This period of time could be the ideal
target for anti-inflammatory treatments. On the other hand, the green
clocks indicate the periods of anti-viral activity of the immune system,
these are the periods in which anti-inflammatory therapy should be
avoided.