Figure 1. Diagrammatic representation highlighting the peak of cytokines and immune responses involved in the cytokine release storm (CRS) of COVID-19 . Peak detrimental inflammatory mediators (red) and beneficial adaptive immune response against viral infections (green) are shown during a 24 h time period. The dotted line and the red clock indicate the period between 4:00 pm and midnight in which the detrimental effects of CRS outweighs the beneficial effect of the adaptive immune response. This period of time could be the ideal target for anti-inflammatory treatments. On the other hand, the green clocks indicate the periods of anti-viral activity of the immune system, these are the periods in which anti-inflammatory therapy should be avoided.