Intervention
Information regarding the effect of MS was extracted from a recent systematic review and meta-analysis included in the review mentioned previously(8). This study included trials that evaluate the effect of MS ( 25-50 mg/kg through 20 min) in patients (range of age of 6-18 years) with acute asthma moderate-severe. All children were treated initially with inhaled albuterol (0.15 mg/kg) by facemask or mouthpiece from nebulizer. On completion of this treatment and after of confirmation a peak expiratory flow rate less than 60%, in all children were given a second albuterol treatment, intravenous methylprednisolone, and intravenous magnesium sulfate or placebo (normal saline solution)(17-19) .