Financial support:
This study was partly supported by grants from the National Natural Science Foundation of China (82102879), the Natural Science Foundation of Guangdong Provence (2021A1515012518), the Postdoctoral Research Foundation of China (2021M691468). The funding agencies had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
PI statement: The authors confirm that the Principal Investigator for this paper is Jinzhang Chen and that he has direct clinical responsibility for the subjects.
Word count (abstract): 258; Word count (full text): 2339; Tables: 2; Figures: 4; References: 29