RESULTS
A total of 1612 patients with a clinical history suggestive of DHR to APs were prospectively evaluated in 4 Spanish centres. Among these, full diagnosis could be achieved in 662 patients: 489 were confirmed as CRs (73.86%) and 173 as SRs (26.13%). In 698 subjects the diagnosis of DHR was discarded as they tolerated the culprit AP in the allergological study, and in 252 the diagnosis of DHR or tolerance could not be achieved: 185 could not undergo DPT to the culprit due to age, comorbidities or because it was contraindicated due to the potential severity of the reaction; 65 did not give consent for the DPTs; and 2 were excluded due to pregnancy (Figure 2).