Materials and Methods
Retrospective cohort of 167 consecutive patients who received an IE diagnosis, according to Duke’s modified criteria, from January 2010 to December 2015, in a Brazilian tertiary university hospital. There were no exclusion criteria.
Primary endpoint was all-cause in-hospital mortality, defined as any death occurred during the index hospitalization, regardless of hospital length of stay. This outcome was analyzed according to the treatment received, clinical vs. surgical. Data from medical records were collected and reviewed by two independent reviewers. In case of disagreement, a third review was performed.
Descriptive data were expressed as mean ± standard deviation (SD) or median and interquartile range (Q1-Q3). Statistical analyses were performed using the statistical package SPSS (version 18.0; SPSS Inc, Chigaco, IL, USA). Categorical variables were analyzed using Chi-square Test, while continuous variables were analyzed using Student’s T-test or Mann-Whitney U test, according to the distribution pattern. Logistic regression was used for univariate analyses. Multivariate analysis model was proceeded to identify independent predictors of mortality. A two-sided p -value lower than 0.05 was considered significant for all analyses. This study was reviewed and approved by the institution’s research ethics committee (CAAE:40755515900005327).