Pregnancy complications in relation to having diagnosed or undiagnosed Marfan syndrome
Before the Marfan syndrome diagnosis, “Pregnancy”, “Pregnancy loss”, and “Delivery” were not affected, whereas after the Marfan syndrome diagnosis “Delivery” was significantly reduced, HR: 0.60 (95% CI: 0.43-0.85) (Figure 2).
None of the subgroups had significant outcomes both in the undiagnosed as well as in the diagnosed women with Marfan syndrome.
However, before the Marfan diagnosis, the following subgroups was significantly increased: In the main group Pregnancy “Complication related to vagina”, HR: 27.2 (95% CI: 2.3-315.0) and “Preeclampsia” (HR: 2.25 (95% CI: 1.11-4.60)), and in the main group Delivery “Complications, others” (HR: 1.57 95% CI: 1.04-2.36)) (Figure 4).
After the Marfan syndrome diagnosis, the main group Pregnancy “Complication related to cervix” HR: 17.5 (95% CI: 1.9-157.7) was significantly increased, as was in the main group Pregnancy loss “Late abortion” (HR: 3.90 (95% CI: 1.21-12.56)) and “Extra uterine pregnancy” (HR: 3.90 (95% CI: 1.58-9.59)), and in main group Delivery “Infection” (HR: 25.5 (95% CI: 2.6-247.1)), and “Sectio” (HR: 2.33 (95% CI: 1.52-3.57)).