Pregnancy complications in relation to having diagnosed or
undiagnosed Marfan syndrome
Before the Marfan syndrome diagnosis, “Pregnancy”, “Pregnancy loss”,
and “Delivery” were not affected, whereas after the Marfan syndrome
diagnosis “Delivery” was significantly reduced, HR: 0.60 (95% CI:
0.43-0.85) (Figure 2).
None of the subgroups had significant outcomes both in the undiagnosed
as well as in the diagnosed women with Marfan syndrome.
However, before the Marfan diagnosis, the following subgroups was
significantly increased: In the main group Pregnancy “Complication
related to vagina”, HR: 27.2 (95% CI: 2.3-315.0) and “Preeclampsia”
(HR: 2.25 (95% CI: 1.11-4.60)), and in the main group Delivery
“Complications, others” (HR: 1.57 95% CI: 1.04-2.36)) (Figure 4).
After the Marfan syndrome diagnosis, the main group Pregnancy
“Complication related to cervix” HR: 17.5 (95% CI: 1.9-157.7) was
significantly increased, as was in the main group Pregnancy loss “Late
abortion” (HR: 3.90 (95% CI: 1.21-12.56)) and “Extra uterine
pregnancy” (HR: 3.90 (95% CI: 1.58-9.59)), and in main group Delivery
“Infection” (HR: 25.5 (95% CI: 2.6-247.1)), and “Sectio” (HR: 2.33
(95% CI: 1.52-3.57)).