Conclusions
The current study finding indicated an overall bovine FMD seroprevalence of 19.8% at individual animal and 56.8% at herd level in the study districts. Hence, our result revealed that FMD was prevalent and is an important cattle disease in the study districts and causing significant economic reduction of daily milk yield, abortion, loss of traction power, and death of calves during outbreaks. Multivariable logistic regression analysis revealed that seroprevalence of FMD was statistically associated with age, herd size, district and contact with wildlife as potential risk factors in the district areas of afar region necessitating further investigation and characterization of circulating virus serotypes to apply effective control and prevention measures.