4 Conclusions
Tumor necrosis at 90% cut-off in localized disease is prognostic of
survival on a non-HDMTX based backbone, though best outcomes are seen
with 100%TN, but 70%TN and other cut-offs require further exploration.
A lower cut-off of 70%(or other) in metastatic disease could be used
for prognostication. Amputation, male gender predicts poor histological
necrosis.