3.5 Patterns of relapse
Of the 114 patients in the whole cohort who relapsed or progressed, it was metastatic in the majority (92.0%, n=46) of good responders (≥90%TN, n=50) and local (4.0%, n=2) or combined (4.0%, n=2) in the rest. In the corresponding cohort of poor responders (<90% TN, n=64), relapses were metastatic in 82.8% (n=53), local in 7.8% (n=5) and combined in 9.4% (n=6), (p=0.5)
In the localized cohort (n=83), who relapsed or progressed, the event was metastatic in 93.8% (n=30), local and combined in 3.1% each (1 patient each) in those with ≥90%TN (n=32). In cases with <90%TN (n=51), relapses were metastatic in 82.4% (n=42), local in 9.8% (n=5) and combined in 7.8% (n=4), (p=0.5)
In the similar cohort with metastatic disease (n=31), relapses were metastatic in 88.8% (n=16), local and combined in 5.6% each (n=1 in each) in those with ≥90%TN (n=18). In cases with <90%TN (n=13), metastatic relapses were seen in 84.6% (n=11) and combined in 15.4% (n=2), (p=0.5)