Insulin resistance and Lactobacilus.
Hundreds of studies have attempted to find an efficacy of LAB on insulin
resistance-associated diseases. However, most of them are underpowered
or have some methodological flaws. Moreover, not all LAB strains have
the same action on insulin resistance 41 and new
better designed studies with the appropriate LAB are required. A large
meta-analysis found that the intake of probiotics resulted in minor but
consistent improvements in several metabolic risk factors in subjects
with metabolic diseases, and in particular in insulin resistance42. Another recent meta-analysis found that an oral
supplementation with probiotics or synbiotics has a small effect in
reducing waist circumference but no effect on body weight or body mass
index (BMI) 43. Kefir, a fermented milk product, was
not found to be more effective than yoghurt in the glycemic control of
obesity, possibly because there are insufficient differences between
both 44. Nrf2 may be involved in diseases associated
with insulin-resistance 45-47. “Ancient foods”, and
particularly those containing Lactobacillus , activate
Nrf248. The microbiome is highly related to insulin
resistance.