Summary
Mycoplasma
hyopneumoniae (M. hyopneumoniae , Mhp) is an etiological agent
that causes mycoplasma pneumonia of swine (MPS), this is a chronic
respiratory disease present in every major swine-producing country
worldwide. It is well elucidated, Mhp infections may downregulate the
host immune system and enhance the infection and replication of other
pathogens. However, the mechanisms of interaction between Mhp and other
pathogens is still missing. Though, additional studies have reported
that several cofactors such as bacteria, vaccination failure, stress or
crowing and other swine viruses in combination with Mhp, lead to MPS.
Aside these cofactors, the co-infection of Mhp with other viruses, such
as Porcine Circovirus, Porcine Reproductive and Respiratory Syndrome
Virus, Swine Influenza Virus, Pseudorabies Virus, and other bacteria,
such as Pasteurella multocida , Actinobacillus
pleuropneumoniae have been widely studied for many years. In this
review, we summarized the co-infection of Mhp with other swine pathogens
based our studies made, the co-infection with other viruses and
bacteria, revealed the interaction mechanism of different pathogens with
Mhp in the host.