References
Allende, R., Laegreid, W. W., Kutish, G. F., Galeota, J. A., Wills, R.
W., & Osorio, F. A. (2000). Porcine reproductive and respiratory
syndrome virus: description of persistence in individual pigs upon
experimental infection. Journal of Virology, 74 (22), 10834-10837.
doi:10.1128/jvi.74.22.10834-10837.2000
Amass, S. F., Clark, L. K., van Alstine, W. G., Bowersock, T. L.,
Murphy, D. A., Knox, K. E., & Albregts, S. R. (1994). Interaction ofMycoplasma hyopneumoniae and Pasteurella multocidainfections in swine. Journal of The American Veterinary Medical
Association, 204 (1), 102-107.
Bao, F., Mi, S., Luo, Q., Guo, H., Tu, C., Zhu, G., & Gong, W. (2018).
Retrospective study of porcine circovirus type 2 infection reveals a
novel genotype PCV2f. Transboundary and Emerging Diseases, 65 (2),
432-440. doi:10.1111/tbed.12721
Baudon, E., Peyre, M., Peiris, M., & Cowling, B. J. (2017).
Epidemiological features of influenza circulation in swine populations:
A systematic review and meta-analysis. Public Library of Science,
12 (6), e0179044. doi:10.1371/journal.pone.0179044
Blanchard, B., Vena, M. M., Cavalier, A., Le Lannic, J., Gouranton, J.,
& Kobisch, M. (1992). Electron microscopic observation of the
respiratory tract of SPF piglets inoculated with Mycoplasma
hyopneumoniae . Veterinary Microbiology, 30 (4), 329-341.
doi:10.1016/0378-1135(92)90020-t
Bourry, O., Fablet, C., Simon, G., & Marois-Crehan, C. (2015). Efficacy
of combined vaccination against Mycoplasma hyopneumoniae and
porcine reproductive and respiratory syndrome virus in dually infected
pigs. Veterinary Microbiology, 180 (3-4), 230-236.
doi:10.1016/j.vetmic.2015.09.015
Bousquet, E., Pommier, P., Wessel-Robert, S., Morvan, H.,
Benoit-Valiergue, H., & Laval, A. (1998). Efficacy of doxycycline in
feed for the control of pneumonia caused by Pasteurella multocidaand Mycoplasma hyopneumoniae in fattening pigs. Veterinary
Record, 143 (10), 269-272. doi:10.1136/vr.143.10.269
Brown, I. H., Alexander, D. J., Chakraverty, P., Harris, P. A., &
Manvell, R. J. (1994). Isolation of an influenza A virus of unusual
subtype (H1N7) from pigs in England, and the subsequent experimental
transmission from pig to pig. Veterinary Microbiology, 39 (1-2),
125-134. doi:10.1016/0378-1135(94)90093-0
Calus, D., Maes, D., Vranckx, K., Villareal, I., Pasmans, F., &
Haesebrouck, F. (2010). Validation of ATP luminometry for rapid and
accurate titration of Mycoplasma hyopneumoniae in Friis medium
and a comparison with the color changing units assay. Journal of
The American Veterinary Medical Association, 83 (3), 335-340.
doi:10.1016/j.mimet.2010.09.001
Caruso, J. P., & Ross, R. F. (1990). Effects of Mycoplasma
hyopneumoniae and Actinobacillus (Haemophilus)pleuropneumoniae infections on alveolar macrophage functions in
swine. American Journal of Veterinary Research, 51 (2), 227-231.
Chae, C. (2005). A review of porcine circovirus 2-associated syndromes
and diseases. Veterinary Journal, 169 (3), 326-336.
doi:10.1016/j.tvjl.2004.01.012
Chae, C. (2011). Vaccinating pigs against Mycoplasma
hyopneumoniae infection: failure to prevent transmission.Veterinary Journal, 188 (1), 7-8. doi:10.1016/j.tvjl.2010.05.032
Chae, C. (2012). Porcine circovirus type 2 and its associated diseases
in Korea. Virus Research, 164 (1-2), 107-113.
doi:10.1016/j.virusres.2011.10.013
Chae, C. (2016). Porcine respiratory disease complex: Interaction of
vaccination and porcine circovirus type 2, porcine reproductive and
respiratory syndrome virus, and Mycoplasma hyopneumoniae .Veterinary Journal, 212 , 1-6. doi:10.1016/j.tvjl.2015.10.030
Christopher-Hennings, J., Nelson, E. A., Althouse, G. C., & Lunney, J.
(2008). Comparative antiviral and proviral factors in semen and vaccines
for preventing viral dissemination from the male reproductive tract and
semen. Animal Health Research Reviews, 9 (1), 59-69.
doi:10.1017/s1466252307001387
Ciprián, A., Pijoan, C., Cruz, T., Camacho, J., & Garza, M. D. L.
(1988). Mycoplasma hyopneumoniae increases the susceptibility of
pigs to experimental Pasteurella multocda pneumonia.Canadian Journal of Veterinary Research, 52 (4), 434-438.
Ciprian, A., Pijoan, C., Cruz, T., Camacho, J., Tortora, J., Colmenares,
G., de la Garza, M. (1988). Mycoplasma hyopneumoniae increases
the susceptibility of pigs to experimental Pasteurella multocidapneumonia. Canadian Journal of Veterinary Research, 52 (4),
434-438.
Cook, B. S., Beddow, J. G., Manso-Silvan, L., Maglennon, G. A., &
Rycroft, A. N. (2016). Selective medium for culture of Mycoplasma
hyopneumoniae . Veterinary Microbiology, 195 , 158-164.
doi:10.1016/j.vetmic.2016.09.022
DeBey, M. C., Jacobson, C. D., & Ross, R. F. (1992). Histochemical and
morphologic changes of porcine airway epithelial cells in response to
infection with Mycoplasma hyopneumoniae . American Journal
of Veterinary Research, 53 (9), 1705-1710.
DeBey, M. C., & Ross, R. F. (1994). Ciliostasis and loss of cilia
induced by Mycoplasma hyopneumoniae in porcine tracheal organ
cultures. Infection and Immunity, 62 (12), 5312-5318.
Deblanc, C., Delgado-Ortega, M., Gorin, S., Berri, M., Paboeuf, F.,
Berthon, P., Simon, G. (2016). Mycoplasma hyopneumoniae does not
affect the interferon-related anti-viral response but predisposes the
pig to a higher level of inflammation following swine influenza virus
infection. Journal of General Virology, 97 (10), 2501-2515.
doi:10.1099/jgv.0.000573
Deblanc, C., Gorin, S., Queguiner, S., Gautier-Bouchardon, A. V., Ferre,
S., Amenna, N., Simon, G. (2012). Pre-infection of pigs withMycoplasma hyopneumoniae modifies outcomes of infection with
European swine influenza virus of H1N1, but not H1N2, subtype.Veterinary Microbiology, 157 (1-2), 96-105.
doi:10.1016/j.vetmic.2011.12.027
Deblanc, C., Robert, F., Pinard, T., Gorin, S., Queguiner, S.,
Gautier-Bouchardon, A. V., Simon, G. (2013). Pre-infection of pigs withMycoplasma hyopneumoniae induces oxidative stress that influences
outcomes of a subsequent infection with a swine influenza virus of H1N1
subtype. Veterinary Microbiology, 162 (2-4), 643-651.
doi:10.1016/j.vetmic.2012.11.028
Dee, S., Otake, S., Oliveira, S., & Deen, J. (2009). Evidence of long
distance airborne transport of porcine reproductive and respiratory
syndrome virus and Mycoplasma hyopneumoniae . Veterinary
Research, 40 (4). doi:ARTN 3910.1051/vetres/2009022
Fablet, C., Marois-Crehan, C., Grasland, B., Simon, G., & Rose, N.
(2016a). Factors associated with herd-level PRRSV infection and age-time
to seroconversion in farrow-to-finish herds. Veterinary
Microbiology, 192 , 10-20. doi:10.1016/j.vetmic.2016.06.006
Fablet, C., Marois-Crehan, C., Grasland, B., Simon, G., & Rose, N.
(2016b). Factors associated with herd-level PRRSV infection and age-time
to seroconversion in farrow-to-finish herds. Veterinary
Microbiology, 192 , 10-20. doi:10.1016/j.vetmic.2016.06.006
Fablet, C., Marois-Crehan, C., Simon, G., Grasland, B., Jestin, A.,
Kobisch, M., Rose, N. (2012). Infectious agents associated with
respiratory diseases in 125 farrow-to-finish pig herds: a
cross-sectional study. Veterinary Microbiology, 157 (1-2),
152-163. doi:10.1016/j.vetmic.2011.12.015
Fablet, C., Marois, C., Dorenlor, V., Eono, F., Eveno, E., Jolly, J. P.,
Rose, N. (2012). Bacterial pathogens associated with lung lesions in
slaughter pigs from 125 herds. Research in Veterinary Science,
93 (2), 627-630. doi:10.1016/j.rvsc.2011.11.002
Fachinger, V., Bischoff, R., Jedidia, S. B., Saalmuller, A., & Elbers,
K. (2008). The effect of vaccination against porcine circovirus type 2
in pigs suffering from porcine respiratory disease complex.Vaccine, 26 (11), 1488-1499. doi:10.1016/j.vaccine.2007.11.053
Fano, E., Pijoan, C., & Dee, S. (2007). Infection dynamics of porcine
reproductive and respiratory syndrome virus in a continuous-flow
population of pigs also infected with Mycoplasma hyopneumoniae .Veterinary Record, 161 (15), 515-520. doi:10.1136/vr.161.15.515
Franzo, G., & Segales, J. (2018). Porcine circovirus 2 (PCV-2) genotype
update and proposal of a new genotyping methodology. Public
Library of Science, 13 (12), e0208585. doi:10.1371/journal.pone.0208585
Freuling, C. M., Muller, T. F., & Mettenleiter, T. C. (2017). Vaccines
against pseudorabies virus (PrV). Veterinary Microbiology, 206 ,
3-9. doi:10.1016/j.vetmic.2016.11.019
Fuentes, M., & Pijoan, C. (1986). Phagocytosis and intracellular
killing of Pasteurella multocida by porcine alveolar macrophages
after infection with pseudorabies virus. Veterinary immunology and
immunopathology, 13 (1-2), 165-172. doi:10.1016/0165-2427(86)90057-7
Haimi-Hakala, M., Halli, O., Laurila, T., Raunio-Saarnisto, M.,
Nokireki, T., Laine, T., Heinonen, M. (2017). Etiology of acute
respiratory disease in fattening pigs in Finland. Porcine Health
Management, 3 , 19. doi:10.1186/s40813-017-0065-2
Hamel, A. L., Lin, L. L., & Nayar, G. P. (1998). Nucleotide sequence of
porcine circovirus associated with postweaning multisystemic wasting
syndrome in pigs. Journal of Virology, 72 (6), 5262-5267.
Hansen, M. S., Pors, S. E., Jensen, H. E., Bille-Hansen, V., Bisgaard,
M., Flachs, E. M., & Nielsen, O. L. (2010). An investigation of the
pathology and pathogens associated with porcine respiratory disease
complex in Denmark. Journal of Comparative Pathology, 143 (2-3),
120-131. doi:10.1016/j.jcpa.2010.01.012
Harper, M., Cox, A. D., Adler, B., & Boyce, J. D. (2011).Pasteurella multocida lipopolysaccharide: the long and the short
of it. Veterinary Microbiology, 153 (1-2), 109-115.
doi:10.1016/j.vetmic.2011.05.022
Harrison, L. R., Colvin, B. M., Greene, J. T., Newman, L. E., & Cole,
J. R., Jr. (1990). Pulmonary edema and hydrothorax in swine produced by
fumonisin B1, a toxic metabolite of Fusarium moniliforme. Journal
of Veterinary Diagnostic Investigation, 2 (3), 217-221.
doi:10.1177/104063879000200312
Hege, R., Zimmermann, W., Scheidegger, R., & Stark, K. D. (2002).
Incidence of reinfections with Mycoplasma hyopneumoniae andActinobacillus pleuropneumoniae in pig farms located in
respiratory-disease-free regions of Switzerland–identification and
quantification of risk factors. Acta Veterinaria Scandinavica,
43 (3), 145-156.
Helm, E. T., Curry, S. M., Schwartz, K. J., Lonergan, S. M., & Gabler,
N. K. (2019). Mycoplasma hyopneumoniae -Lawsonia
intracellularis dual challenge modulates intestinal integrity and
function1. Journal of Animal Science, 97 (6), 2376-2384.
doi:10.1093/jas/skz112
Helm, E. T., Outhouse, A. C., Schwartz, K. J., Dekkers, J. C. M.,
Lonergan, S. M., Rauw, W. M., & Gabler, N. K. (2018). Impact ofMycoplasma hyopneumoniae and Lawsonia intracellularis on
the performance of pigs divergently selected for feed efficiency.Journal of Animal Science, 96 (2), 462-472. doi:10.1093/jas/skx074
Helm, E. T., Outhouse, A. C., Schwartz, K. J., Lonergan, S. M., Curry,
S. M., Dekkers, J. C. M., & Gabler, N. K. (2018). Metabolic adaptation
of pigs to a Mycoplasma hyopneumoniae and Lawsonia
intracellularis dual challenge. Journal of Animal Science,
96 (8), 3196-3207. doi:10.1093/jas/sky220
Iglesias, G., Pijoan, C., & Molitor, T. (1992). Effects of pseudorabies
virus infection upon cytotoxicity and antiviral activities of porcine
alveolar macrophages. Comparative Immunology, Microbiology and
Infectious Diseases, 15 (4), 249-259. doi:10.1016/0147-9571(92)90004-b
Jiang, P., Zhou, N., Chen, X., Zhao, X., Li, D., Wang, F., Zhang, D.
(2015). Integrative analysis of differentially expressed microRNAs of
pulmonary alveolar macrophages from piglets during H1N1 swine influenza
A virus infection. Scientific Reports, 5 , 8167.
doi:10.1038/srep08167
Kavanova, L., Matiaskova, K., Leva, L., Nedbalcova, K., Matiasovic, J.,
Faldyna, M., & Salat, J. (2018). Concurrent infection of
monocyte-derived macrophages with porcine reproductive and respiratory
syndrome virus and Haemophilus parasuis : A role of IFN alpha in
pathogenesis of co-infections. Veterinary Microbiology, 225 ,
64-71. doi:10.1016/j.vetmic.2018.09.016
Krakowka, S., Ellis, J., McNeilly, F., Waldner, C., Rings, D. M., &
Allan, G. (2007). Mycoplasma hyopneumoniae bacterins and porcine
circovirus type 2 (PCV2) infection: induction of postweaning
multisystemic wasting syndrome (PMWS) in the gnotobiotic swine model of
PCV2-associated disease. Canadian Veterinary Journal-Revue
Veterinaire Canadienne, 48 (7), 716-724.
Krakowka, S., Ellis, J. A., Meehan, B., Kennedy, S., McNeilly, F., &
Allan, G. (2000). Viral wasting syndrome of swine: experimental
reproduction of postweaning multisystemic wasting syndrome in
gnotobiotic swine by coinfection with porcine circovirus 2 and porcine
parvovirus. Veterinary Pathology, 37 (3), 254-263.
doi:10.1354/vp.37-3-254
Kureljusic, B., Weissenbacher-Lang, C., Nedorost, N., Stixenberger, D.,
& Weissenbock, H. (2016). Association between Pneumocystis spp .
and co-infections with Bordetella bronchiseptica ,Mycoplasma hyopneumoniae and Pasteurella multocida in
Austrian pigs with pneumonia. Veterinary Journal, 207 , 177-179.
doi:10.1016/j.tvjl.2015.11.003
Labarque, G., Van Gucht, S., Nauwynck, H., Van Reeth, K., & Pensaert,
M. (2003). Apoptosis in the lungs of pigs infected with porcine
reproductive and respiratory syndrome virus and associations with the
production of apoptogenic cytokines. Veterinary Research, 34 (3),
249-260. doi:10.1051/vetres:2003001
Larochelle, R., Magar, R., & D’Allaire, S. (2003). Comparative
serologic and virologic study of commercial swine herds with and without
postweaning multisystemic wasting syndrome. Canadian Journal of
Veterinary Research, 67 (2), 114-120.
LeRoith, T., Hammond, S., Todd, S. M., Ni, Y., Cecere, T., & Pelzer, K.
D. (2011). A modified live PRRSV vaccine and the pathogenic parent
strain induce regulatory T cells in pigs naturally infected withMycoplasma hyopneumoniae . Veterinary Immunology and
Immunopathology, 140 (3-4), 312-316. doi:10.1016/j.vetimm.2010.12.011
Li, B., Du, L., Xu, X., Sun, B., Yu, Z., Feng, Z., He, K. (2015).
Transcription analysis on response of porcine alveolar macrophages to
co-infection of the highly pathogenic porcine reproductive and
respiratory syndrome virus and Mycoplasma hyopneumoniae .Virus Research, 196 , 60-69. doi:10.1016/j.virusres.2014.11.006
Luehrs, A., Siegenthaler, S., Grutzner, N., Grosse Beilage, E., Kuhnert,
P., & Nathues, H. (2017). Occurrence of Mycoplasma hyorhinisinfections in fattening pigs and association with clinical signs and
pathological lesions of Enzootic Pneumonia. Veterinary
Microbiology, 203 , 1-5. doi:10.1016/j.vetmic.2017.02.001
Lunney, J. K., Fang, Y., Ladinig, A., Chen, N., Li, Y., Rowland, B., &
Renukaradhya, G. J. (2016). Porcine Reproductive and Respiratory
Syndrome Virus (PRRSV): Pathogenesis and Interaction with the Immune
System. Annual Review of Animal Biosciences, 4 , 129-154.
doi:10.1146/annurev-animal-022114-111025
Maes, D., Segales, J., Meyns, T., Sibila, M., Pieters, M., &
Haesebrouck, F. (2008). Control of Mycoplasma hyopneumoniaeinfections in pigs. Veterinary Microbiology, 126 (4), 297-309.
doi:10.1016/j.vetmic.2007.09.008
Maes, D., Sibila, M., Kuhnert, P., Segales, J., Haesebrouck, F., &
Pieters, M. (2018). Update on Mycoplasma hyopneumoniae infections
in pigs: Knowledge gaps for improved disease control.Transboundary and Emerging Diseases, 65 Suppl 1 , 110-124.
doi:10.1111/tbed.12677
Maes, D., Verdonck, M., Deluyker, H., & de Kruif, A. (1996). Enzootic
pneumonia in pigs. Veterinary Quarterly, 18 (3), 104-109.
doi:10.1080/01652176.1996.9694628
Marois, C., Gottschalk, M., Morvan, H., Fablet, C., Madec, F., &
Kobisch, M. (2009). Experimental infection of SPF pigs withActinobacillus pleuropneumoniae serotype 9 alone or in
association with Mycoplasma hyopneumoniae . Veterinary
Microbiology, 135 (3-4), 283-291. doi:10.1016/j.vetmic.2008.09.061
Meehan, B. M., McNeilly, F., Todd, D., Kennedy, S., Jewhurst, V. A.,
Ellis, J. A., Allan, G. M. (1998). Characterization of novel circovirus
DNAs associated with wasting syndromes in pigs. Journal of General
Virology, 79 ( Pt 9) , 2171-2179. doi:10.1099/0022-1317-79-9-2171
Meiners, C., Loesken, S., Doehring, S., Starick, E., Pesch, S., Maas,
A., Grosse Beilage, E. (2014). Field study on swine influenza virus
(SIV) infection in weaner pigs and sows. Tierarztl Prax Ausg G
Grosstiere Nutztiere, 42 (6), 351-359. doi:10.15653/tpg-131130
Michiels, A., Arsenakis, I., Boyen, F., Krejci, R., Haesebrouck, F., &
Maes, D. (2017). Efficacy of one dose vaccination against experimental
infection with two Mycoplasma hyopneumoniae strains. Bmc
Veterinary Research, 13 (1), 274. doi:10.1186/s12917-017-1195-0
Michiels, A., Arsenakis, I., Matthijs, A., Boyen, F., Haesaert, G.,
Audenaert, K., Maes, D. (2018). Clinical impact of deoxynivalenol,
3-acetyl-deoxynivalenol and 15-acetyl-deoxynivalenol on the severity of
an experimental Mycoplasma hyopneumoniae infection in pigs.Bmc Veterinary Research, 14 (1), 190.
doi:10.1186/s12917-018-1502-4
Michiels, A., Vranckx, K., Piepers, S., Del Pozo Sacristan, R.,
Arsenakis, I., Boyen, F., Maes, D. (2017). Impact of diversity ofMycoplasma hyopneumoniae strains on lung lesions in slaughter
pigs. Veterinary Research, 48 (1), 2.
doi:10.1186/s13567-016-0408-z
Mores, M. A. Z., Oliveira Filho, J. X., Rebelatto, R., Klein, C. S.,
Barcellos, D. E. N., & Coldebella, A., & Morés, N. (2015). Aspectos
patológicos e microbiológicos das doenças respiratórias em suínos de
terminação no Brasil. Pesquisa Veterinaria Brasileira (35),
725-733. doi:10.1590/S0100-736X2015000800004
Morris, C. R., Gardner, I. A., Hietala, S. K., & Carpenter, T. E.
(1995). Enzootic pneumonia: comparison of cough and lung lesions as
predictors of weight gain in swine. Canadian Journal of Veterinary
Research, 59 (3), 197-204.
Neumann, E. J., Kliebenstein, J. B., Johnson, C. D., Mabry, J. W., Bush,
E. J., Seitzinger, A. H., Zimmerman, J. J. (2005). Assessment of the
economic impact of porcine reproductive and respiratory syndrome on
swine production in the United States. Journal of The American
Veterinary Medical Association, 227 (3), 385-392.
doi:10.2460/javma.2005.227.385
Obradovic, M. R., & Wilson, H. L. (2019). Immune response and
protection against Lawsonia intracellularis infections in pigs.Veterinary Immunology and Immunopathology, 219 , 109959.
doi:10.1016/j.vetimm.2019.109959
Opriessnig, T., Gimenez-Lirola, L. G., & Halbur, P. G. (2011).
Polymicrobial respiratory disease in pigs. Animal Health Research
Reviews, 12 (2), 133-148. doi:10.1017/s1466252311000120
Opriessnig, T., & Halbur, P. G. (2012). Concurrent infections are
important for expression of porcine circovirus associated disease.Virus Research, 164 (1-2), 20-32.
doi:10.1016/j.virusres.2011.09.014
Opriessnig, T., Madson, D. M., Schalk, S., Brockmeier, S., Shen, H. G.,
Beach, N. M., Halbur, P. G. (2011). Porcine circovirus type 2 (PCV2)
vaccination is effective in reducing disease and PCV2 shedding in semen
of boars concurrently infected with PCV2 and Mycoplasma
hyopneumoniae . Theriogenology, 76 (2), 351-360.
doi:10.1016/j.theriogenology.2011.02.014
Opriessnig, T., Thacker, E. L., Yu, S., Fenaux, M., Meng, X. J., &
Halbur, P. G. (2004). Experimental reproduction of postweaning
multisystemic wasting syndrome in pigs by dual infection withMycoplasma hyopneumoniae and porcine circovirus type 2.Veterinary Pathology, 41 (6), 624-640. doi:10.1354/vp.41-6-624
Otake, S., Dee, S., Corzo, C., Oliveira, S., & Deen, J. (2010).
Long-distance airborne transport of infectious PRRSV andMycoplasma hyopneumoniae from a swine population infected with
multiple viral variants. Veterinary Microbiology, 145 (3-4),
198-208. doi:10.1016/j.vetmic.2010.03.028
Pallares, F. J., Halbur, P. G., Opriessnig, T., Sorden, S. D., Villar,
D., Janke, B. H., Hoffman, L. J. (2002). Porcine circovirus type 2
(PCV-2) coinfections in US field cases of postweaning multisystemic
wasting syndrome (PMWS). Journal of Veterinary Diagnostic
Investigation, 14 (6), 515-519. doi:10.1177/104063870201400614
Park, C., Jeong, J., Kang, I., Choi, K., Park, S. J., & Chae, C.
(2016). Increased fucosyl glycoconjugate by Mycoplasma
hyopneumoniae enhances adherences of Pasteurella multocida type
A in the ciliated epithelial cells of the respiratory tract. Bmc
Veterinary Research, 12 , 25. doi:10.1186/s12917-016-0650-7
Park, C., Oh, Y., Seo, H. W., Han, K., & Chae, C. (2013). Comparative
effects of vaccination against porcine circovirus type 2 (PCV2) and
porcine reproductive and respiratory syndrome virus (PRRSV) in a
PCV2-PRRSV challenge model. Clinical and Vaccine Immunology,
20 (3), 369-376. doi:10.1128/cvi.00497-12
Park, S. J., Seo, H. W., Park, C., & Chae, C. (2014). Interaction
between single-dose Mycoplasma hyopneumoniae and porcine
reproductive and respiratory syndrome virus vaccines on dually infected
pigs. Research in Veterinary Science, 96 (3), 516-522.
doi:10.1016/j.rvsc.2014.03.009
Patterson, A. R., & Opriessnig, T. (2010). Epidemiology and horizontal
transmission of porcine circovirus type 2 (PCV2). Animal Health
Research Reviews, 11 (2), 217-234. doi:10.1017/s1466252310000162
Peng, Z., Ouyang, T., Pang, D., Ma, T., Chen, X., Guo, N., Ren, L.
(2016). Pseudorabies virus can escape from CRISPR-Cas9-mediated
inhibition. Virus Research, 223 , 197-205.
doi:10.1016/j.virusres.2016.08.001
Pieters, M., Pijoan, C., Fano, E., & Dee, S. (2009). An assessment of
the duration of Mycoplasma hyopneumoniae infection in an
experimentally infected population of pigs. Veterinary
Microbiology, 134 (3-4), 261-266. doi:10.1016/j.vetmic.2008.08.016
Pogranichniy, R. M., Yoon, K. J., Harms, P. A., Sorden, S. D., &
Daniels, M. (2002). Case-control study on the association of porcine
circovirus type 2 and other swine viral pathogens with postweaning
multisystemic wasting syndrome. Journal of Veterinary Diagnostic
Investigation Official Publication of the American Association of
Veterinary Laboratory Diagnosticians Inc, 14 (6), 449.
Pomeranz, L. E., Reynolds, A. E., & Hengartner, C. J. (2005). Molecular
biology of pseudorabies virus: impact on neurovirology and veterinary
medicine. Microbiology and Molecular Biology Reviews, 69 (3),
462-500. doi:10.1128/mmbr.69.3.462-500.2005
Posa, R., Magyar, T., Stoev, S. D., Glavits, R., Donko, T., Repa, I., &
Kovacs, M. (2013a). Use of computed tomography and histopathologic
review for lung lesions produced by the interaction betweenMycoplasma hyopneumoniae and fumonisin mycotoxins in pigs.Veterinary Pathology, 50 (6), 971-979.
doi:10.1177/0300985813480510
Posa, R., Magyar, T., Stoev, S. D., Glavits, R., Donko, T., Repa, I., &
Kovacs, M. (2013b). Use of Computed Tomography and Histopathologic
Review for Lung Lesions Produced by the Interaction BetweenMycoplasma hyopneumoniae and Fumonisin Mycotoxins in Pigs.Veterinary Pathology, 50 (6), 971-979.
doi:10.1177/0300985813480510
Posa, R., Stoev, S., Kovacs, M., Donko, T., Repa, I., & Magyar, T.
(2016). A comparative pathological finding in pigs exposed to fumonisin
B1 and/or Mycoplasma hyopneumoniae . Toxicology and
Industrial Health, 32 (6), 998-1012. doi:10.1177/0748233714543735
Rech, R. R., Gava, D., Silva, M. C., Fernandes, L. T., Haach, V.,
Ciacci-Zanella, J. R., & Schaefer, R. (2018). Porcine respiratory
disease complex after the introduction of H1N1/2009 influenza virus in
Brazil. Zoonoses Public Health, 65 (1), e155-e161.
doi:10.1111/zph.12424
Roberts, N. E., & Almond, G. W. (2003). Infection of growing swine with
porcine reproductive and respiratory syndrome virus and Mycoplasma
hyopneumoniae –effects on growth, serum metabolites, and insulin-like
growth factor-I. Canadian Veterinary Journal-Revue Veterinaire
Canadienne, 44 (1), 31-37.
Ross, R. F. (2006). Pasteurella multocida and its role in porcine
pneumonia. Animal Health Research Reviews, 7 (1-2), 13-29.
doi:10.1017/s1466252307001211
Rowland, R. R., Lawson, S., Rossow, K., & Benfield, D. A. (2003).
Lymphoid tissue tropism of porcine reproductive and respiratory syndrome
virus replication during persistent infection of pigs originally exposed
to virus in utero. Veterinary Microbiology, 96 (3), 219-235.
doi:10.1016/j.vetmic.2003.07.006
Sassu, E. L., Bosse, J. T., Tobias, T. J., Gottschalk, M., Langford, P.
R., & Hennig-Pauka, I. (2018). Update on Actinobacillus
pleuropneumoniae -knowledge, gaps and challenges. Transboundary
and Emerging Diseases, 65 Suppl 1 , 72-90. doi:10.1111/tbed.12739
Segales, J. (2012). Porcine circovirus type 2 (PCV2) infections:
clinical signs, pathology and laboratory diagnosis. Virus
Research, 164 (1-2), 10-19. doi:10.1016/j.virusres.2011.10.007
Segales, J., Olvera, A., Grau-Roma, L., Charreyre, C., Nauwynck, H.,
Larsen, L., Allan, G. (2008). PCV-2 genotype definition and
nomenclature. Veterinary Record, 162 (26), 867-868.
doi:10.1136/vr.162.26.867
Seo, H. W., Park, S. J., Park, C., & Chae, C. (2014). Interaction of
porcine circovirus type 2 and Mycoplasma hyopneumoniae vaccines
on dually infected pigs. Vaccine, 32 (21), 2480-2486.
doi:10.1016/j.vaccine.2014.02.088
Shibata, I., Okada, M., Urono, K., Samegai, Y., Ono, M., Sakano, T., &
Sato, S. (1998). Experimental dual infection of cesarean-derived,
colostrum-deprived pigs with Mycoplasma hyopneumoniae and
Pseudorabies virus. Journal of Veterinary Science, 60 (3),
295-300. doi:10.1292/jvms.60.295
Shimizu, M., Yamada, S., Kawashima, K., Ohashi, S., Shimizu, S., &
Ogawa, T. (1996). Changes of lymphocyte subpopulations in pigs infected
with porcine reproductive and respiratory syndrome (PRRS) virus.Veterinary immunology and immunopathology, 50 (1-2), 19-27.
doi:10.1016/0165-2427(95)05494-4
Sibila, M., Fort, M., Nofrarias, M., de Rozas, A. P., Galindo-Cardiel,
I., Mateu, E., & Segales, J. (2012). Simultaneous Porcine Circovirus
Type 2 and Mycoplasma hyopneumoniae Co-inoculation does not
Potentiate Disease in Conventional Pigs. Journal of Comparative
Pathology, 147 (2-3), 285-295. doi:10.1016/j.jcpa.2012.01.003
Sibila, M., Fort, M., Nofrarias, M., Perez de Rozas, A.,
Galindo-Cardiel, I., Mateu, E., & Segales, J. (2012). Simultaneous
porcine circovirus type 2 and Mycoplasma hyopneumoniaeco-inoculation does not potentiate disease in conventional pigs.Journal of Comparative Pathology, 147 (2-3), 285-295.
doi:10.1016/j.jcpa.2012.01.003
Simionatto, S., Marchioro, S. B., Maes, D., & Dellagostin, O. A.
(2013). Mycoplasma hyopneumoniae : from disease to vaccine
development. Veterinary Microbiology, 165 (3-4), 234-242.
doi:10.1016/j.vetmic.2013.04.019
Solano, G. I., Bautista, E., Molitor, T. W., Segales, J., & Pijoan, C.
(1998). Effect of porcine reproductive and respiratory syndrome virus
infection on the clearance of Haemophilus parasuis by porcine
alveolar macrophages. Canadian Journal of Veterinary Research,
62 (4), 251-256.
Steenhard, N. R., Jungersen, G., Kokotovic, B., Beshah, E., Dawson, H.
D., Urban, J. F., Jr., Thamsborg, S. M. (2009). Ascaris suum infection
negatively affects the response to a Mycoplasma hyopneumoniaevaccination and subsequent challenge infection in pigs. Vaccine,
27 (37), 5161-5169. doi:10.1016/j.vaccine.2009.05.075
Stoev, S. D. (2013). Food safety and increasing hazard of mycotoxin
occurrence in foods and feeds. Critical Reviews in Food Science
and Nutrition, 53 (9), 887-901. doi:10.1080/10408398.2011.571800
Tao, Y., Shu, J., Chen, J., Wu, Y., & He, Y. (2019). A concise review
of vaccines against Mycoplasma hyopneumoniae . Research in
Veterinary Science, 123 , 144-152. doi:10.1016/j.rvsc.2019.01.007
Tassis, P. D., Tsakmakidis, I., Papatsiros, V. G., Koulialis, D., Nell,
T., Brellou, G., & Tzika, E. D. (2017). A randomized controlled study
on the efficacy of a novel combination vaccine against enzootic
pneumonia (Mycoplasma hyopneumoniae ) and porcine Circovirus type
2 (PCV2) in the presence of strong maternally derived PCV2 immunity in
pigs. Bmc Veterinary Research, 13 (1), 91.
doi:10.1186/s12917-017-1014-7
Taubenberger, J. K., & Morens, D. M. (2008). The pathology of influenza
virus infections. Annual Review of Pathology, 3 , 499-522.
doi:10.1146/annurev.pathmechdis.3.121806.154316
Thacker, E. L., Halbur, P. G., Ross, R. F., Thanawongnuwech, R., &
Thacker, B. J. (1999). Mycoplasma hyopneumoniae potentiation of
porcine reproductive and respiratory syndrome virus-induced pneumonia.Journal of Clinical Microbiology, 37 (3), 620-627.
Thacker, E. L., Thacker, B. J., & Janke, B. H. (2001). Interaction
between Mycoplasma hyopneumoniae and swine influenza virus.Journal of Clinical Microbiology, 39 (7), 2525-2530.
doi:10.1128/jcm.39.7.2525-2530.2001
Thacker, E. L., Thacker, B. J., Kuhn, M., Hawkins, P. A., & Waters, W.
R. (2000). Evaluation of local and systemic immune responses induced by
intramuscular injection of a Mycoplasma hyopneumoniae bacterin to
pigs. American Journal of Veterinary Research, 61 (11), 1384-1389.
doi:10.2460/ajvr.2000.61.1384
Thanawongnuwech, R., Thacker, B., Halbur, P., & Thacker, E. L. (2004).
Increased production of proinflammatory cytokines following infection
with porcine reproductive and respiratory syndrome virus andMycoplasma hyopneumoniae . Clinical and Diagnostic
Laboratory Immunology, 11 (5), 901-908.
doi:10.1128/cdli.11.5.901-908.2004
Thanawongnuwech, R., & Thacker, E. L. (2003). Interleukin-10,
interleukin-12, and interferon-gamma levels in the respiratory tract
following Mycoplasma hyopneumoniae and PRRSV infection in pigs.Viral Immunology, 16 (3), 357-367. doi:10.1089/088282403322396154
Thanawongnuwech, R., Thacker, E. L., & Halbur, P. G. (1997). Effect of
porcine reproductive and respiratory syndrome virus (PRRSV) (isolate
ATCC VR-2385) infection on bactericidal activity of porcine pulmonary
intravascular macrophages (PIMs): in vitro comparisons with pulmonary
alveolar macrophages (PAMs). Veterinary immunology and
immunopathology, 59 (3-4), 323-335. doi:10.1016/s0165-2427(97)00078-0
Thanawongnuwech, R., Young, T. F., Thacker, B. J., & Thacker, E. L.
(2001). Differential production of proinflammatory cytokines: in vitro
PRRSV and Mycoplasma hyopneumoniae co-infection model.Veterinary immunology and immunopathology, 79 (1-2), 115-127.
doi:10.1016/s0165-2427(01)00243-4
Tjornehoj, K., Eriksen, L., Aalbaek, B., & Nansen, P. (1992).
Interaction between Ascaris suum and Pasteurella multocida in the
lungs of mice. Parasitology Research, 78 (6), 525-528.
doi:10.1007/bf00931575
Tocqueville, V., Kempf, I., Paboeuf, F., & Marois-Crehan, C. (2017).
Quantification of Pasteurella multocida in experimentally
infected pigs using a real-time PCR assay. Research in Veterinary
Science, 112 , 177-184. doi:10.1016/j.rvsc.2017.04.016
Tomas, A., Fernandes, L. T., Valero, O., & Segales, J. (2008). A
meta-analysis on experimental infections with porcine circovirus type 2
(PCV2). Veterinary Microbiology, 132 (3-4), 260-273.
doi:10.1016/j.vetmic.2008.05.023
Tzika, E. D., Tassis, P. D., Koulialis, D., Papatsiros, V. G., Nell, T.,
Brellou, G., & Tsakmakidis, I. (2015). Field efficacy study of a novel
ready-to-use vaccine against Mycoplasma hyopneumoniae and porcine
circovirus type 2 in a Greek farm. Porcine Health Management, 1 .
doi:UNSP 1510.1186/s40813-015-0006-x
Van Alstine, W. G., Stevenson, G. W., & Kanitz, C. L. (1996). Porcine
reproductive and respiratory syndrome virus does not exacerbateMycoplasma hyopneumoniae infection in young pigs.Veterinary Microbiology, 49 (3-4), 297-303.
doi:10.1016/0378-1135(95)00191-3
Vangroenweghe, F. A., Labarque, G. G., Piepers, S., Strutzberg-Minder,
K., & Maes, D. (2015). Mycoplasma hyopneumoniae infections in
peri-weaned and post-weaned pigs in Belgium and The Netherlands:
Prevalence and associations with climatic conditions. Veterinary
Journal, 205 (1), 93-97. doi:10.1016/j.tvjl.2015.03.028
Vicca, J., Maes, D., Thermote, L., Peeters, J., Haesebrouck, F., & de
Kruif, A. (2002). Patterns of Mycoplasma hyopneumoniae infections
in Belgian farrow-to-finish pig herds with diverging disease-course.Journal of Veterinary Medicine. B, Infectious Diseases and
Veterinary Public Health, 49 (7), 349-353.
Vranckx, K., Maes, D., Calus, D., Villarreal, I., Pasmans, F., &
Haesebrouck, F. (2011). Multiple-locus variable-number tandem-repeat
analysis is a suitable tool for differentiation of Mycoplasma
hyopneumoniae strains without cultivation. Journal of Clinical
Microbiology, 49 (5), 2020-2023. doi:10.1128/jcm.00125-11
Vranckx, K., Maes, D., Sacristan Rdel, P., Pasmans, F., & Haesebrouck,
F. (2012). A longitudinal study of the diversity and dynamics ofMycoplasma hyopneumoniae infections in pig herds.Veterinary Microbiology, 156 (3-4), 315-321.
doi:10.1016/j.vetmic.2011.11.007
Wang, H., Feng, Z., Wu, Y., Wei, Y., Gan, Y., Hua, L., Shao, G. (2016).
The effects of Mycoplasma hyopneumoniae on porcine circovirus
type 2 replication in vitro PK-15 cells. Research in Veterinary
Science, 105 , 56-61. doi:10.1016/j.rvsc.2016.01.015
Weissenbacher-Lang, C., Kureljusic, B., Nedorost, N., Matula, B.,
Schiessl, W., Stixenberger, D., & Weissenbock, H. (2016). Retrospective
Analysis of Bacterial and Viral Co-Infections in Pneumocystis
spp . Positive Lung Samples of Austrian Pigs with Pneumonia.Public
Library of Science, 11 (7), e0158479. doi:10.1371/journal.pone.0158479
Wellenberg, G. J., Stockhofe-Zurwieden, N., Boersma, W. J. A., Jong, M.
F., De, & Elbers, A. R. W. (2004). The presence of co-infections in
pigs with clinical signs of PMWS in The Netherlands: a case-control
study. Research in Veterinary Science, 77 (2), 177-184.
Wills, R. W., Doster, A. R., Galeota, J. A., Sur, J. H., & Osorio, F.
A. (2003). Duration of infection and proportion of pigs persistently
infected with porcine reproductive and respiratory syndrome virus.Journal of Clinical Microbiology, 41 (1), 58-62.
doi:10.1128/jcm.41.1.58-62.2003
Wills, R. W., Zimmerman, J. J., Yoon, K. J., Swenson, S. L., McGinley,
M. J., Hill, H. T., Nelson, E. A. (1997). Porcine reproductive and
respiratory syndrome virus: a persistent infection. Veterinary
Microbiology, 55 (1-4), 231-240. doi:10.1016/s0378-1135(96)01337-5
Yao, J., Qin, Y., Zeng, Y., Ouyang, K., Chen, Y., Huang, W., & Wei, Z.
(2019). Genetic analysis of porcine circovirus type 2 (PCV2) strains
between 2002 and 2016 reveals PCV2 mutant predominating in porcine
population in Guangxi, China. Bmc Veterinary Research, 15 (1),
118. doi:10.1186/s12917-019-1859-z
Yazawa, S., Okada, M., Ono, M., Fujii, S., Okuda, Y., Shibata, I., &
Kida, H. (2004). Experimental dual infection of pigs with an H1N1 swine
influenza virus (A/Sw/Hok/2/81) and Mycoplasma hyopneumoniae .Veterinary Microbiology, 98 (3-4), 221-228.
doi:10.1016/j.vetmic.2003.11.005
Zhang, H. R., Lunney, J. K., Baker, R. B., & Opriessnig, T. (2011).
Cytokine and chemokine mRNA expression profiles in tracheobronchial
lymph nodes from pigs singularly infected or coinfected with porcine
circovirus type 2 (PCV2) and Mycoplasma hyopneumoniae (MHYO).Veterinary Immunology and Immunopathology, 140 (1-2), 152-158.
doi:10.1016/j.vetimm.2010.11.019
Zhang, N., Gao, P., Yin, B., Li, J., Wu, T., Kuang, Y., Li, J. (2019).
Cathepsin L promotes secretory IgA response by participating in antigen
presentation pathways during Mycoplasma Hyopneumoniae infection.Public Library of Science, 14 (4), e0215408.
doi:10.1371/journal.pone.0215408
Zomborszky-Kovács, M., Kovács, F., Horn, P., Vetési, F., Repa, I.,
Tornyos, G., & Tóth, Á. (2002). Investigations into the time- and
dose-dependent effect of fumonisin B 1 in order to determine tolerable
limit values in pigs. Livestock Production Science, 76 (3),
251-256.