Figure Legends

Figure 1. Metformin and Rapamycin could decrease the incidence of
age-related diseases.

In terms of mechanism, metformin and rapamycin achieve similar calorie
restriction effect in different ways. Metformin can activate AMPK like
calorie restriction and further cause a series of pathways changes,
which could arouse anti-aging effects such as Inhibition of
pro-inflammatory effect and ROS detoxification. Rapamycin can inhibit
mTORC1, which relate to Autophagy and Protein Synthesis pathway.