Figure Legends Figure 1. Metformin and Rapamycin could decrease the incidence of age-related diseases. In terms of mechanism, metformin and rapamycin achieve similar calorie restriction effect in different ways. Metformin can activate AMPK like calorie restriction and further cause a series of pathways changes, which could arouse anti-aging effects such as Inhibition of pro-inflammatory effect and ROS detoxification. Rapamycin can inhibit mTORC1, which relate to Autophagy and Protein Synthesis pathway.